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Martine Roussel
St. Jude Children's Research Hospital, United States of America

Faculty Member: CELL BIOLOGY > Cell growth & division [ since 24 August 2001 ]
[ Evaluations ]
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Evaluations

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Terzian T, Suh YA, …, Van Pelt CS, Lozano G
Genes Dev 2008 May 15 22(10):1337-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 4 Jul 2008

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
Wiedemeyer R, Brennan C, …, Futreal PA, Chin L
Cancer Cell 2008 Apr 13(4):355-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 7 May 2008


Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.
Solomon DA, Kim JS, …, Jean W, Waldman T
Cancer Res 2008 Apr 15 68(8):2564-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 7 May 2008

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.
Wajapeyee N, Serra RW, …, Mahalingam M, Green MR
Cell 2008 Feb 8 132(3):363-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Abraham / Martine Roussel / Scott Lowe / Simon Cook / Heng Zhu
Evaluated 11 Mar 2008


Endogenous human microRNAs that suppress breast cancer metastasis.
Tavazoie SF, Alarcón C, …, Gerald WL, Massagué J
Nature 2008 Jan 10 451(7175):147-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dinah Singer / Martine Roussel / Charles Streuli
Evaluated 22 Jan 2008

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, …, Sanes JR, Lichtman JW
Nature 2007 Nov 1 450(7166):56-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kees Jalink / Alain Ghysen / Jonathan Sweedler / Liqun Luo / Catherine Krull / Markus Ruegg / Stanley Appel / David P. Wolfer / Andy Groves / Bruce Cumming / Guoping Feng / Edvard I. Moser / Etienne Joly / Martine Roussel
Evaluated 22 Jan 2008

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
Feng Z, Hu W, …, Cordon-Cardo C, Levine AJ
Proc Natl Acad Sci U S A 2007 Oct 16 104(42):16633-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 1 Nov 2007

Myc deletion rescues Apc deficiency in the small intestine.
Sansom OJ, Meniel VS, …, Clevers H, Clarke AR
Nature 2007 Apr 5 446(7136):676-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Salvador Aznar-Benitah / Mariann Bienz / Martine Roussel
Evaluated 30 Apr 2007

CHD5 is a tumor suppressor at human 1p36.
Bagchi A, Papazoglu C, …, Vogel H, Mills AA
Cell 2007 Feb 9 128(3):459-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Duojia Pan / Martine Roussel
Evaluated 9 Mar 2007

p21 delays tumor onset by preservation of chromosomal stability.
Barboza JA, Liu G, …, El-Naggar AK, Lozano G
Proc Natl Acad Sci U S A 2006 Dec 26 103(52):19842-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 25 Jan 2007

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Noguera-Troise I, Daly C, …, Yancopoulos GD, Thurston G
Nature 2006 Dec 21 444(7122):1032-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel / Christer Betsholtz / Deborah Andrew
Evaluated 25 Jan 2007


Inactivation of the p53 pathway in retinoblastoma.
Laurie NA, Donovan SL, …, Jochemsen AG, Dyer MA
Nature 2006 Nov 2 444(7115):61-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 12 Dec 2006

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Giuriato S, Ryeom S, …, Folkman J, Felsher DW
Proc Natl Acad Sci U S A 2006 Oct 31 103(44):16266-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 1 Dec 2006

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Chen ML, Xu PZ, …, Pandolfi PP, Hay N
Genes Dev 2006 Jun 15 20(12):1569-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 20 Jul 2006


Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells.
White PM, Doetzlhofer A, …, Groves AK, Segil N
Nature 2006 Jun 22 441(7096):984-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 19 Jul 2006

Generation of a functional mammary gland from a single stem cell.
Shackleton M, Vaillant F, …, Lindeman GJ, Visvader JE
Nature 2006 Jan 5 439(7072):84-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Giovanni Neri / Charles Streuli / Martine Roussel / Peter Hartmann / Matthew John Smalley
Evaluated 13 Apr 2006


Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.
Tovar C, Rosinski J, …, Heimbrook DC, Vassilev LT
Proc Natl Acad Sci U S A 2006 Feb 7 103(6):1888-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 12 Apr 2006

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Ramiro AR, Jankovic M, …, Nussenzweig A, Nussenzweig MC
Nature 2006 Mar 2 440(7080):105-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 24 Jan 2006

Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor.
Takahashi C, Contreras B, …, Hunt JL, Ewen ME
Nat Genet 2006 Jan 38(1):118-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 3 Jan 2006


Cdc2-cyclin E complexes regulate the G1/S phase transition.
Aleem E, Kiyokawa H, Kaldis P
Nat Cell Biol 2005 Aug 7(8):831-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel / Michele Pagano / Jane Endicott
Evaluated 29 Jul 2005

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
Dupuy AJ, Akagi K, …, Copeland NG, Jenkins NA
Nature 2005 Jul 14 436(7048):221-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel / Hans Clevers / Donald Rio / Liqun Luo
Evaluated 29 Jul 2005

Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein.
Sage C, Huang M, …, Corey DP, Chen ZY
Science 2005 Feb 18 307(5712):1114-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 9 Mar 2005

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Romer JT, Kimura H, …, Rubin LL, Curran T
Cancer Cell 2004 Sep 6(3):229-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin / Martine Roussel
Evaluated 3 Dec 2004

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.
Matheu A, Pantoja C, …, Klatt P, Serrano M
Genes Dev 2004 Nov 15 18(22):2736-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 3 Dec 2004

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer.
Shachaf CM, Kopelman AM, …, Contag CH, Felsher DW
Nature 2004 Oct 28 431(7012):1112-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 13 Oct 2004

The ubiquitin ligase COP1 is a critical negative regulator of p53.
Dornan D, Wertz I, …, Koeppen H, Dixit VM
Nature 2004 May 6 429(6987):86-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel
Evaluated 27 May 2004

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts.
Murry CE, Soonpaa MH, …, Williams DA, Field LJ
Nature 2004 Apr 8 428(6983):664-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Ekblom / Martine Roussel
Evaluated 4 May 2004

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev LT, Vu BT, …, Fotouhi N, Liu EA
Science 2004 Feb 6 303(5659):844-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ulf Pettersson / Liang Tong / Martine Roussel / Jane Endicott / William Kaelin / Dorothee Kern
Evaluated 16 Mar 2004

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
Rubin JB, Kung AL, …, Luster AD, Segal RA
Proc Natl Acad Sci U S A 2003 Nov 11 100(23):13513-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 8 Dec 2003

Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Smith KS, Chanda SK, …, van Lohuizen M, Cleary ML
Mol Cell 2003 Aug 12(2):393-400 [abstract on PubMed] [related articles] [order article]
Selected by | Martine Roussel
Evaluated 29 Oct 2003

Prospective identification of tumorigenic breast cancer cells.
Al-Hajj M, Wicha MS, …, Morrison SJ, Clarke MF
Proc Natl Acad Sci U S A 2003 Apr 1 100(7):3983-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andreas Trumpp / Kermit Carraway / Martine Roussel
Evaluated 27 Jun 2003


Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.
Kim SH, Mitchell M, …, Llanos S, Peters G
Proc Natl Acad Sci U S A 2003 Jan 7 100(1):211-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 20 Feb 2003

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.
Hemann MT, Fridman JS, …, Hannon GJ, Lowe SW
Nat Genet 2003 Mar 33(3):396-400 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martine Roussel / Errol C. Friedberg
Evaluated 14 Feb 2003

E2F4 loss suppresses tumorigenesis in Rb mutant mice.
Lee EY, Cam H, …, Lees JA, Dynlacht BD
Cancer Cell 2002 Dec 2(6):463-72 [abstract on PubMed] [related articles] [order article]
Selected by | Martine Roussel
Evaluated 6 Feb 2003

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.
García-Cao I, García-Cao M, …, Blasco MA, Serrano M
EMBO J 2002 Nov 15 21(22):6225-35 [abstract on PubMed] [related articles] [order article]
Selected by | Martine Roussel
Evaluated 13 Dec 2002

A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells.
Tsai RY, McKay RD
Genes Dev 2002 Dec 1 16(23):2991-3003 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Brent Cochran / Martine Roussel / Lucio Comai
Evaluated 11 Dec 2002

DNA ligase IV suppresses medulloblastoma formation.
Lee Y, McKinnon PJ
Cancer Res 2002 Nov 15 62(22):6395-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 11 Dec 2002

The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.
Leung KM, Po LS, …, Ho HT, Poon RY
Cancer Res 2002 Sep 1 62(17):4890-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 26 Sep 2002

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest.
Rowland BD, Denissov SG, …, Bernards R, Peeper DS
Cancer Cell 2002 Jul 2(1):55-65 [abstract on PubMed] [related articles] [order article]
Selected by | Martine Roussel
Evaluated 5 Aug 2002

Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2.
Clark PA, Llanos S, Peters G
Oncogene 2002 Jul 4 21(29):4498-507 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 2 Aug 2002

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
Ogawa H, Ishiguro K, …, Livingston DM, Nakatani Y
Science 2002 May 10 296(5570):1132-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ron Prywes / Martine Roussel / Stephen Dalton / Thomas Jenuwein
Evaluated 5 Jun 2002

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.
Pelengaris S, Khan M, Evan GI
Cell 2002 May 3 109(3):321-34 [abstract on PubMed] [related articles] [order article]
Selected by | Martine Roussel / Scott Lowe
Evaluated 30 May 2002

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Schmitt CA, Fridman JS, …, Hoffman RM, Lowe SW
Cell 2002 May 3 109(3):335-46 [abstract on PubMed] [related articles] [order article]
Selected by | Martine Roussel
Evaluated 29 May 2002

Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis.
Pani L, Horal M, Loeken MR
Genes Dev 2002 Mar 15 16(6):676-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel / David Sassoon
Evaluated 2 Apr 2002

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.
Shvarts A, Brummelkamp TR, …, Spits H, Bernards R
Genes Dev 2002 Mar 15 16(6):681-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 2 Apr 2002

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo.
Tolbert D, Lu X, …, Tantama M, Van Dyke T
Mol Cell Biol 2002 Jan 22(1):370-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel / Yue Xiong
Evaluated 16 Jan 2002

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
Rodier G, Montagnoli A, …, Pagano M, Meloche S
EMBO J 2001 Dec 3 20(23):6672-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 9 Jan 2002

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
Groszer M, Erickson R, …, Liu X, Wu H
Science 2001 Dec 7 294(5549):2186-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Laura Johnston / Giovanni Neri / Martine Roussel
Evaluated 4 Jan 2002

ARF function does not require p53 stabilization or Mdm2 relocalization.
Korgaonkar C, Zhao L, Modestou M, Quelle DE
Mol Cell Biol 2002 Jan 22(1):196-206 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 4 Jan 2002

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
Mayo LD, Donner DB
Proc Natl Acad Sci U S A 2001 Sep 25 98(20):11598-603 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 25 Oct 2001

Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system.
Lipinski MM, Macleod KF, …, Crowley D, Jacks T
EMBO J 2001 Jul 2 20(13):3402-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martine Roussel
Evaluated 2 Oct 2001

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