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William Kaelin
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, United States of America

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 24 August 2001 ]
[ Evaluations ]
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Evaluations

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
Aragonés J, Schneider M, …, Maxwell P, Carmeliet P
Nat Genet 2008 Feb 40(2):170-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin
Evaluated 27 Feb 2008

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.
MacKenzie ED, Selak MA, …, Watson DG, Gottlieb E
Mol Cell Biol 2007 May 27(9):3282-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin
Evaluated 27 Feb 2008

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Engelman JA, Zejnullahu K, …, Cantley LC, Jänne PA
Science 2007 May 18 316(5827):1039-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin / Kermit Carraway
Evaluated 22 May 2007


p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.
Sano M, Minamino T, …, Zou Y, Komuro I
Nature 2007 Mar 22 446(7134):444-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin
Evaluated 20 Mar 2007

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.
Sharma SV, Gajowniczek P, …, Haber DA, Settleman J
Cancer Cell 2006 Nov 10(5):425-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Weber / William Kaelin
Evaluated 8 Jan 2007

A loss-of-function RNA interference screen for molecular targets in cancer.
Ngo VN, Davis RE, …, Powell J, Staudt LM
Nature 2006 May 4 441(7089):106-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Astar Winoto / William Kaelin / Giulio Superti-Furga / Andrew D. Sharrocks
Evaluated 11 May 2006

Histone demethylation by a family of JmjC domain-containing proteins.
Tsukada Y, Fang J, …, Tempst P, Zhang Y
Nature 2006 Feb 16 439(7078):811-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin / Eric Selker / Thomas Jenuwein
Evaluated 31 Jan 2006

Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
Weissleder R, Kelly K, …, Shtatland T, Josephson L
Nat Biotechnol 2005 Nov 23(11):1418-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vincent Rotello / William Kaelin / Ross Weatherman
Evaluated 12 Jan 2006

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.
Garrison JL, Kunkel EJ, Hegde RS, Taunton J
Nature 2005 Jul 14 436(7048):285-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tracy Palmer / Martin Pool / William Kaelin / Stephan Nussberger
Evaluated 10 Aug 2005

Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1.
Besemer J, Harant H, …, Dascher-Nadel C, Lindley IJ
Nature 2005 Jul 14 436(7048):290-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Pool / Tracy Palmer / William Kaelin
Evaluated 10 Aug 2005

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
Raval RR, Lau KW, …, Harris AL, Ratcliffe PJ
Mol Cell Biol 2005 Jul 25(13):5675-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin
Evaluated 8 Aug 2005

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.
Rankin EB, Higgins DF, …, Bradfield CA, Haase VH
Mol Cell Biol 2005 Apr 25(8):3163-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Kodadek / William Kaelin
Evaluated 12 Apr 2005

Genome-wide RNAi analysis of growth and viability in Drosophila cells.
Boutros M, Kiger AA, …, Perrimon N, Heidelberg Fly Array Consortium
Science 2004 Feb 6 303(5659):832-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ulf Pettersson / William Kaelin
Evaluated 14 Jan 2005

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Romer JT, Kimura H, …, Rubin LL, Curran T
Cancer Cell 2004 Sep 6(3):229-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin / Martine Roussel
Evaluated 13 Oct 2004

HIF activation by pH-dependent nucleolar sequestration of VHL.
Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S
Nat Cell Biol 2004 Jul 6(7):642-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ronald Conaway / Jonathan Gleadle / Marie-Alda Gilles-Gonzalez / William Kaelin
Evaluated 9 Aug 2004

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
Lynch TJ, Bell DW, …, Settleman J, Haber DA
N Engl J Med 2004 May 20 350(21):2129-39 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin / Joachim Herz / Michael B. Yaffe / Charles Brenner
Evaluated 10 May 2004

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
Paez JG, Jänne PA, …, Johnson BE, Meyerson M
Science 2004 Jun 4 304(5676):1497-500 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin / Patricia C. Weber / Joachim Herz / Charles Streuli / Alfred Wittinghofer / Charles Brenner
Evaluated 10 May 2004

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Berns K, Hijmans EM, …, Beijersbergen RL, Bernards R
Nature 2004 Mar 25 428(6981):431-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharad Kumar / Julian Downward / William Kaelin
Evaluated 4 May 2004

A resource for large-scale RNA-interference-based screens in mammals.
Paddison PJ, Silva JM, …, Elledge SJ, Hannon GJ
Nature 2004 Mar 25 428(6981):427-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin
Evaluated 4 May 2004

A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast.
Ahmed S, Palermo C, Wan S, Walworth NC
Mol Cell Biol 2004 May 24(9):3660-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Teresa Wang / William Kaelin
Evaluated 4 May 2004

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev LT, Vu BT, …, Fotouhi N, Liu EA
Science 2004 Feb 6 303(5659):844-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ulf Pettersson / Liang Tong / Martine Roussel / Jane Endicott / William Kaelin / Dorothee Kern
Evaluated 23 Mar 2004

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha.
Hagen T, Taylor CT, Lam F, Moncada S
Science 2003 Dec 12 302(5652):1975-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin
Evaluated 23 Jan 2004

Suppression of BRAF(V599E) in human melanoma abrogates transformation.
Hingorani SR, Jacobetz MA, …, Herlyn M, Tuveson DA
Cancer Res 2003 Sep 1 63(17):5198-202 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin
Evaluated 13 Oct 2003

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.
Ortega S, Prieto I, …, Malumbres M, Barbacid M
Nat Genet 2003 Sep 35(1):25-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hiroto Okayama / Sergio Moreno / William Kaelin
Evaluated 24 Sep 2003

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Narita M, N¿nez S, …, Hannon GJ, Lowe SW
Cell 2003 Jun 13 113(6):703-16 [abstract on PubMed] [related articles] [order article]
Selected by | William Kaelin
Evaluated 19 Sep 2003

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry.
Sage J, Miller AL, …, Wysocki JM, Jacks T
Nature 2003 Jul 10 424(6945):223-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dafna Bar-Sagi / Anthony Means / William Kaelin / Anjana Rao / Richard Pestell
Evaluated 5 Sep 2003

Genetics of gene expression surveyed in maize, mouse and man.
Schadt EE, Monks SA, …, Stoughton RB, Friend SH
Nature 2003 Mar 20 422(6929):297-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks / William Kaelin / Michael O'Donovan
Evaluated 10 Jun 2003

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
Grossman SR, Deato ME, …, Nakatani Y, Livingston DM
Science 2003 Apr 11 300(5617):342-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Means / William Kaelin
Evaluated 6 Jun 2003

RNA interference targeting Fas protects mice from fulminant hepatitis.
Song E, Lee SK, …, Shankar P, Lieberman J
Nat Med 2003 Mar 9(3):347-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Phillip Zamore / William Kaelin
Evaluated 9 May 2003

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Ayad NG, Rankin S, …, Gygi S, Kirschner MW
Cell 2003 Apr 4 113(1):101-13 [abstract on PubMed] [related articles] [order article]
Selected by | William Kaelin / Antony Carr
Evaluated 9 May 2003

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
Kamath RS, Fraser AG, …, Zipperlen P, Ahringer J
Nature 2003 Jan 16 421(6920):231-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sally Leevers / Jonathan Hodgkin / Yasushi Okazaki / William Kaelin / Eaton E. Lattman
Evaluated 12 Feb 2003

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome.
Nickerson ML, Warren MB, …, Zbar B, Schmidt LS
Cancer Cell 2002 Aug 2(2):157-64 [abstract on PubMed] [related articles] [order article]
Selected by | William Kaelin
Evaluated 22 Oct 2002

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
Rapisarda A, Uranchimeg B, …, Shoemaker RH, Melillo G
Cancer Res 2002 Aug 1 62(15):4316-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin
Evaluated 22 Oct 2002

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
Bykov VJ, Issaeva N, …, Wiman KG, Selivanova G
Nat Med 2002 Mar 8(3):282-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin
Evaluated 16 Jul 2002

Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy.
Dor Y, Djonov V, …, Goelman G, Keshet E
EMBO J 2002 Apr 15 21(8):1939-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Kaelin
Evaluated 5 Jun 2002

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.
Flores ER, Tsai KY, …, McKeon F, Jacks T
Nature 2002 Apr 4 416(6880):560-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin
Evaluated 1 May 2002

A system for stable expression of short interfering RNAs in mammalian cells.
Brummelkamp TR, Bernards R, Agami R
Science 2002 Apr 19 296(5567):550-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sharad Kumar / Ashok Venkitaraman / William Kaelin / Michael Meisterernst / Richard Vile / David Glover / Andrea Barta
Evaluated 1 May 2002

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, …, Schofield CJ, Ratcliffe PJ
Cell 2001 Oct 5 107(1):43-54 [abstract on PubMed] [related articles] [order article]
Selected by | Stefan Jentsch / Ronald Conaway / William Kaelin / Ueli Schibler / David Greenstein / Andrius Kazlauskas / Christer Betsholtz
Evaluated 6 Nov 2001

A conserved family of prolyl-4-hydroxylases that modify HIF.
Bruick RK, McKnight SL
Science 2001 Nov 9 294(5545):1337-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ronald Conaway / William Kaelin / Ueli Schibler
Evaluated 6 Nov 2001

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