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David Wotton
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, United States of America

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 30 October 2003 ]
[ Evaluations ]
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Evaluations

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Dawlaty MM, Malureanu L, …, Grosschedl R, van Deursen JM
Cell 2008 Apr 4 133(1):103-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton / Paul Clarke / Titia Sixma
Evaluated 18 Apr 2008

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.
Padua D, Zhang XH, …, Gomis RR, Massagué J
Cell 2008 Apr 4 133(1):66-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton / Richard Klemke
Evaluated 18 Apr 2008

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
Ivanov AV, Peng H, …, Zhou MM, Rauscher FJ
Mol Cell 2007 Dec 14 28(5):823-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton / Salvador Aznar-Benitah
Evaluated 21 Dec 2007

GSK-3-mediated phosphorylation enhances Maf-transforming activity.
Rocques N, Abou Zeid N, …, Eychène A, Pouponnot C
Mol Cell 2007 Nov 30 28(4):584-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Woodgett / David Wotton
Evaluated 20 Dec 2007

MicroRNA control of Nodal signalling.
Martello G, Zacchigna L, …, Wessely O, Piccolo S
Nature 2007 Sep 13 449(7159):183-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton / Herbert Steinbeisser
Evaluated 26 Sep 2007

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Levy L, Howell M, …, Episkopou V, Hill CS
Mol Cell Biol 2007 Sep 27(17):6068-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 13 Aug 2007

High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene.
Bruna A, Darken RS, …, Baselga J, Seoane J
Cancer Cell 2007 Feb 11(2):147-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 22 Mar 2007

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.
Li W, Tu D, Brunger AT, Ye Y
Nature 2007 Mar 15 446(7133):333-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Kodadek / David Wotton
Evaluated 22 Mar 2007

Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.
Roscic A, Möller A, …, Lüdi KS, Schmitz ML
Mol Cell 2006 Oct 6 24(1):77-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 24 Oct 2006

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.
He W, Dorn DC, …, Moore MA, Massagué J
Cell 2006 Jun 2 125(5):929-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 27 Jun 2006

Identification of phosphatases for Smad in the BMP/DPP pathway.
Chen HB, Shen J, Ip YT, Xu L
Genes Dev 2006 Mar 15 20(6):648-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 3 Apr 2006

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Cha TL, Zhou BP, …, Otte AP, Hung MC
Science 2005 Oct 14 310(5746):306-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Tsichlis / David Wotton
Evaluated 18 Jan 2006

Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Levy L, Hill CS
Mol Cell Biol 2005 Sep 25(18):8108-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 28 Sep 2005

SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast.
Shin JA, Choi ES, …, Park SD, Jang YK
Mol Cell 2005 Sep 16 19(6):817-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 26 Sep 2005

PIASx acts as an Elk-1 coactivator by facilitating derepression.
Yang SH, Sharrocks AD
EMBO J 2005 Jun 15 24(12):2161-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 29 Jun 2005

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.
Ozdamar B, Bose R, …, Zhang Y, Wrana JL
Science 2005 Mar 11 307(5715):1603-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Victor Thannickal / Keith Mostov / David Wotton / David Bilder / Valeri Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias / Andreas Wodarz / Francisco Sanchez-Madrid
Evaluated 23 Mar 2005

A mechanism for inhibiting the SUMO pathway.
Boggio R, Colombo R, …, Draetta GF, Chiocca S
Mol Cell 2004 Nov 19 16(4):549-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Murray Stewart / Robert Krug / David Wotton
Evaluated 3 Dec 2004

Identification of a SUMO-binding motif that recognizes SUMO-modified proteins.
Song J, Durrin LK, …, Krontiris TG, Chen Y
Proc Natl Acad Sci U S A 2004 Oct 5 101(40):14373-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 7 Oct 2004

Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation.
Bai Y, Yang C, …, Elly C, Liu YC
Mol Cell 2004 Sep 10 15(5):825-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 28 Sep 2004

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis.
Aubin J, Davy A, Soriano P
Genes Dev 2004 Jun 15 18(12):1482-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam / David Wotton / Claudio Stern
Evaluated 24 Jun 2004

Hierarchical recruitment of polycomb group silencing complexes.
Wang L, Brown JL, …, Kassis JA, Jones RS
Mol Cell 2004 Jun 4 14(5):637-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton / Leonie Ringrose
Evaluated 21 Jun 2004

Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses.
Zhou W, Ryan JJ, Zhou H
J Biol Chem 2004 Jul 30 279(31):32262-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 21 Jun 2004

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Seoane J, Le HV, …, Anderson SA, Massagué J
Cell 2004 Apr 16 117(2):211-23 [abstract on PubMed] [related articles] [order article]
Selected by | Chaya Kalcheim / David Wotton / John Rubenstein
Evaluated 12 May 2004

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.
Teixeira MT, Arneric M, Sperisen P, Lingner J
Cell 2004 Apr 30 117(3):323-35 [abstract on PubMed] [related articles] [order article]
Selected by | Titia De Lange / David Wotton
Evaluated 12 May 2004

A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A.
Zhang L, Duan CJ, …, Logsdon CD, Simeone DM
Mol Cell Biol 2004 Mar 24(5):2169-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 5 Mar 2004

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.
Pera EM, Ikeda A, Eivers E, De Robertis EM
Genes Dev 2003 Dec 15 17(24):3023-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden / David Wotton
Evaluated 21 Jan 2004

Polycomb CBX7 has a unifying role in cellular lifespan.
Gil J, Bernard D, Martínez D, Beach D
Nat Cell Biol 2004 Jan 6(1):67-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton
Evaluated 19 Jan 2004

Histone sumoylation is associated with transcriptional repression.
Shiio Y, Eisenman RN
Proc Natl Acad Sci U S A 2003 Nov 11 100(23):13225-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wotton
Evaluated 28 Nov 2003

Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.
Zhang Q, Yoshimatsu Y, …, Frisch SM, Goodman RH
Cell 2003 Oct 17 115(2):177-86 [abstract on PubMed] [related articles] [order article]
Selected by | David Wotton / Miles Wilkinson
Evaluated 28 Nov 2003

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