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Timothy Yen
Institute for Cancer Research, Fox Chase Cancer Center, United States of America

Faculty Member: CELL BIOLOGY > Cell growth & division [ since 3 September 2001 ]
[ Evaluations ]
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Evaluations

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient.
Fuller BG, Lampson MA, …, Stukenberg PT, Kapoor TM
Nature 2008 May 7 [abstract on PubMed] [related articles] [full text]
Selected by | Anna Akhmanova / Timothy Yen
Evaluated 23 May 2008

Dynamics of inner kinetochore assembly and maintenance in living cells.
Hemmerich P, Weidtkamp-Peters S, …, Erliandri I, Diekmann S
J Cell Biol 2008 Mar 24 180(6):1101-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen
Evaluated 14 Apr 2008

Aurora B Kinase-Dependent Recruitment of hZW10 and hROD to Tensionless Kinetochores.
Famulski JK, Chan GK
Curr Biol 2007 Dec 18 17(24):2143-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen
Evaluated 15 Jan 2008

BUB1 mediation of caspase-independent mitotic death determines cell fate.
Niikura Y, Dixit A, …, Perkins G, Kitagawa K
J Cell Biol 2007 Jul 16 178(2):283-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen
Evaluated 2 Aug 2007

Surveillance mechanism linking Bub1 loss to the p53 pathway.
Gjoerup OV, Wu J, …, Jat PS, Roberts TM
Proc Natl Acad Sci U S A 2007 May 15 104(20):8334-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 6 Jun 2007

Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint.
Braunstein I, Miniowitz S, Moshe Y, Hershko A
Proc Natl Acad Sci U S A 2007 Mar 20 104(12):4870-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 4 Apr 2007

Propagation of centromeric chromatin requires exit from mitosis.
Jansen LE, Black BE, Foltz DR, Cleveland DW
J Cell Biol 2007 Mar 12 176(6):795-805 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen / Gary Karpen
Evaluated 30 Mar 2007

PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.
Baumann C, Körner R, Hofmann K, Nigg EA
Cell 2007 Jan 12 128(1):101-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Wordeman / Kerry Bloom / Timothy Yen / Andrew Belmont
Evaluated 30 Mar 2007

A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
Kimura H, Takizawa N, …, Fukagawa T, Okawa K
J Cell Biol 2006 Nov 6 175(3):389-400 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Karolin Luger / Timothy Yen / Sui Huang
Evaluated 28 Nov 2006

Muscle-specific microRNA miR-206 promotes muscle differentiation.
Kim HK, Lee YS, …, Malhotra A, Dutta A
J Cell Biol 2006 Aug 28 174(5):677-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 1 Sep 2006

The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.
Jeganathan KB, Malureanu L, van Deursen JM
Nature 2005 Dec 15 438(7070):1036-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen / Jun Qin
Evaluated 9 Mar 2006

Chromosome alignment and segregation regulated by ubiquitination of survivin.
Vong QP, Cao K, …, Iglesias PA, Zheng Y
Science 2005 Dec 2 310(5753):1499-504 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Zhen-Qiang Pan / Timothy Yen
Evaluated 19 Jan 2006

A contractile nuclear actin network drives chromosome congression in oocytes.
Lénárt P, Bacher CP, …, Terasaki M, Ellenberg J
Nature 2005 Aug 11 436(7052):812-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Leah Keshet / Prasad Jallepalli / Manfred Schliwa / Timothy Yen / Thomas Ried
Evaluated 14 Sep 2005

Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase.
Casaletto JB, Nutt LK, …, Hunt T, Kornbluth S
J Cell Biol 2005 Apr 11 169(1):61-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mary Dasso / Rebecca Heald / Timothy Yen / Arp Schnittger
Evaluated 25 Apr 2005

A mitotic septin scaffold required for Mammalian chromosome congression and segregation.
Spiliotis ET, Kinoshita M, Nelson WJ
Science 2005 Mar 18 307(5716):1781-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 30 Mar 2005

Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis.
Salic A, Waters JC, Mitchison TJ
Cell 2004 Sep 3 118(5):567-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen / Peter Jackson / Claire Walczak / Prasad Jallepalli
Evaluated 12 Oct 2004

Timing and checkpoints in the regulation of mitotic progression.
Meraldi P, Draviam VM, Sorger PK
Dev Cell 2004 Jul 7(1):45-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen / Kevin Hardwick / Bruce McEwen
Evaluated 20 Jul 2004

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells.
Lindon C, Pines J
J Cell Biol 2004 Jan 19 164(2):233-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen / Iain Hagan
Evaluated 4 Mar 2004

The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.
Mollinari C, Reynaud C, …, Kleman JP, Margolis RL
Dev Cell 2003 Aug 5(2):295-307 [abstract on PubMed] [related articles] [order article]
Selected by | William Earnshaw / Timothy Yen
Evaluated 9 Sep 2003

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin.
Ohi R, Coughlin ML, Lane WS, Mitchison TJ
Dev Cell 2003 Aug 5(2):309-21 [abstract on PubMed] [related articles] [order article]
Selected by | Linda Wordeman / Claire Walczak / Timothy Yen
Evaluated 3 Sep 2003

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.
Babu JR, Jeganathan KB, …, Kang-Decker N, van Deursen JM
J Cell Biol 2003 Feb 3 160(3):341-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathon Pines / Timothy Yen
Evaluated 20 Mar 2003

Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis.
Khodjakov A, Copenagle L, …, Compton DA, Kapoor TM
J Cell Biol 2003 Mar 3 160(5):671-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Claire Walczak / Timothy Yen / Rebecca Heald
Evaluated 19 Mar 2003

Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena.
Mochizuki K, Fine NA, Fujisawa T, Gorovsky MA
Cell 2002 Sep 20 110(6):689-99 [abstract on PubMed] [related articles] [order article]
Selected by | Mitzi Kuroda / Timothy Yen
Evaluated 12 Dec 2002

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Volpe TA, Kidner C, …, Grewal SI, Martienssen RA
Science 2002 Sep 13 297(5588):1833-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | L. Alison McInnes / Robin Allshire / Rivka Dikstein / Frank Lyko / Timothy Yen / Kerry Bloom / James Carrington / Thomas Jenuwein
Evaluated 8 Oct 2002

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2.
Martin-Lluesma S, Stucke VM, Nigg EA
Science 2002 Sep 27 297(5590):2267-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen / Peter Jackson / Kathleen Gould
Evaluated 4 Oct 2002

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.
Hagting A, Den Elzen N, …, Peters JM, Pines J
J Cell Biol 2002 Jun 24 157(7):1125-37 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kathleen Gould / Timothy Yen / David Morgan
Evaluated 19 Jul 2002

Emi1 is required for cytostatic factor arrest in vertebrate eggs.
Reimann JD, Jackson PK
Nature 2002 Apr 25 416(6883):850-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Yen / Joan Ruderman / Angel Nebreda
Evaluated 17 May 2002

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles.
Joseph J, Tan SH, …, McNally JG, Dasso M
J Cell Biol 2002 Feb 18 156(4):595-602 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfred Wittinghofer / Timothy Yen
Evaluated 9 May 2002

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores.
Fraschini R, Beretta A, …, Lucchini G, Piatti S
EMBO J 2001 Dec 3 20(23):6648-59 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 1 Mar 2002

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.
Biggins S, Murray AW
Genes Dev 2001 Dec 1 15(23):3118-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Steven Reed / Timothy Yen
Evaluated 24 Jan 2002

The human decatenation checkpoint.
Deming PB, Cistulli CA, …, Downes CS, Kaufmann WK
Proc Natl Acad Sci U S A 2001 Oct 9 98(21):12044-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 14 Nov 2001

An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells.
Belgareh N, Rabut G, …, Ellenberg J, Doye V
J Cell Biol 2001 Sep 17 154(6):1147-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 8 Nov 2001

A potential role for human cohesin in mitotic spindle aster assembly.
Gregson HC, Schmiesing JA, …, Zhou S, Yokomori K
J Biol Chem 2001 Dec 14 276(50):47575-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Yen
Evaluated 30 Oct 2001

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