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Yigong Shi

No longer a member of F1000[ 11-JUL-2001 - 20-MAY-2008 ]
[ Sponsorship ] [ Evaluations ]
Sponsorship

Yigong Shi sponsors free access to F1000 for Tsinghua University, Beijing, China. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

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Evaluations

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.
George NM, Evans JJ, Luo X
Genes Dev 2007 Aug 1 21(15):1937-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / David Andrews
Evaluated 13 Aug 2007

The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release.
Ott M, Norberg E, …, Zhivotovsky B, Orrenius S
J Biol Chem 2007 Sep 21 282(38):27633-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Atan Gross / Yigong Shi
Evaluated 10 Aug 2007

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
Brooks C, Wei Q, …, Xie ZJ, Dong Z
Proc Natl Acad Sci U S A 2007 Jul 10 104(28):11649-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 10 Aug 2007

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.
Challa M, Malladi S, …, White K, Bratton SB
EMBO J 2007 Jul 11 26(13):3144-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 10 Aug 2007

Molecular recognition of p53 and MDM2 by USP7/HAUSP.
Sheng Y, Saridakis V, …, Arrowsmith CH, Frappier L
Nat Struct Mol Biol 2006 Mar 13(3):285-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 12 Jul 2006

The structure of FADD and its mode of interaction with procaspase-8.
Carrington PE, Sandu C, …, Wei Y, Werner MH
Mol Cell 2006 Jun 9 22(5):599-610 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Douglas Green / Yigong Shi
Evaluated 7 Jul 2006

A common allosteric site and mechanism in caspases.
Scheer JM, Romanowski MJ, Wells JA
Proc Natl Acad Sci U S A 2006 May 16 103(20):7595-600 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 6 Jul 2006

Crystal structure and mechanism of human lysine-specific demethylase-1.
Stavropoulos P, Blobel G, Hoelz A
Nat Struct Mol Biol 2006 Jul 13(7):626-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / Song Tan
Evaluated 6 Jul 2006

Requirement of cytochrome c for apoptosis in human cells.
Matapurkar A, Lazebnik Y
Cell Death Differ 2006 Dec 13(12):2062-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 6 Jul 2006

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells.
Suzuki A, Raya A, …, Rodríguez-Esteban C, Izpisúa Belmonte JC
Proc Natl Acad Sci U S A 2006 Jul 5 103(27):10294-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 6 Jul 2006

Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c.
Hansen TM, Smith DJ, Nagley P
Cell Death Differ 2006 Jul 13(7):1181-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 9 Dec 2005

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.
Kim HE, Du F, Fang M, Wang X
Proc Natl Acad Sci U S A 2005 Dec 6 102(49):17545-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 8 Dec 2005

Structure and chromosomal DNA binding of the SWIRM domain.
Qian C, Zhang Q, …, Walsh MJ, Zhou MM
Nat Struct Mol Biol 2005 Dec 12(12):1078-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / Vitaly Citovsky
Evaluated 7 Dec 2005

Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer.
Yu X, Wang L, …, Wang X, Akey CW
J Mol Biol 2006 Jan 20 355(3):577-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharad Kumar / Yigong Shi
Evaluated 7 Dec 2005

Malonate-assisted purification of human caspases.
Scheer JM, Wells JA, Romanowski MJ
Protein Expr Purif 2005 May 41(1):148-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 2 Jun 2005

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.
Hao Z, Duncan GS, …, Wang X, Mak TW
Cell 2005 May 20 121(4):579-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / Sharad Kumar / John Abrams / Astar Winoto
Evaluated 1 Jun 2005

Proapoptotic BAX and BAK control multiple initiator caspases.
Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ
EMBO Rep 2005 Apr 6(4):379-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 20 May 2005

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation.
Yamashita M, Ying SX, …, Deng CX, Zhang YE
Cell 2005 Apr 8 121(1):101-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / Michele Pagano
Evaluated 19 May 2005

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Walensky LD, Kung AL, …, Verdine GL, Korsmeyer SJ
Science 2004 Sep 3 305(5689):1466-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi / John Abrams
Evaluated 8 Sep 2004

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.
Li L, Thomas RM, …, Wang X, Harran PG
Science 2004 Sep 3 305(5689):1471-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi / Ding Xue / John Abrams
Evaluated 8 Sep 2004

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Chae HJ, Kim HR, …, Lipton SA, Reed JC
Mol Cell 2004 Aug 13 15(3):355-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 8 Sep 2004

Discovery of an allosteric site in the caspases.
Hardy JA, Lam J, …, O'Brien T, Wells JA
Proc Natl Acad Sci U S A 2004 Aug 24 101(34):12461-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Amy Barrios / Yigong Shi
Evaluated 8 Sep 2004

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost TK, Sun C, …, Zou H, Fesik SW
J Med Chem 2004 Aug 26 47(18):4417-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / John Abrams
Evaluated 8 Sep 2004

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways.
Birchenall-Roberts MC, Fu T, …, Kim SJ, Ruscetti FW
J Biol Chem 2004 Jun 11 279(24):25605-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 30 Apr 2004

Caspase activation inhibits proteasome function during apoptosis.
Sun XM, Butterworth M, …, Ciechanover A, Cohen GM
Mol Cell 2004 Apr 9 14(1):81-93 [abstract on PubMed] [related articles] [order article]
Selected by | David Wallach / Ding Xue / Yigong Shi
Evaluated 27 Apr 2004

Bifunctional killing activity encoded by conserved reaper proteins.
Chen P, Ho SI, Shi Z, Abrams JM
Cell Death Differ 2004 Jul 11(7):704-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 27 Apr 2004

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis.
Conery AR, Cao Y, …, Ko TC, Luo K
Nat Cell Biol 2004 Apr 6(4):366-72 [abstract on PubMed] [related articles] [order article]
Selected by | Yigong Shi
Evaluated 27 Apr 2004

IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding.
Zachariou A, Tenev T, …, Steller H, Meier P
EMBO J 2003 Dec 15 22(24):6642-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 7 Jan 2004

A novel role for XIAP in copper homeostasis through regulation of MURR1.
Burstein E, Ganesh L, …, Nabel GJ, Duckett CS
EMBO J 2004 Jan 14 23(1):244-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 6 Jan 2004

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
Wang X, Wu YC, …, Mitani S, Xue D
Science 2003 Nov 28 302(5650):1563-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 5 Dec 2003

The BRCT domain is a phospho-protein binding domain.
Yu X, Chini CC, …, Mer G, Chen J
Science 2003 Oct 24 302(5645):639-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 5 Dec 2003

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.
Potts PR, Singh S, …, Thompson CB, Deshmukh M
J Cell Biol 2003 Nov 24 163(4):789-99 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi / Girish Putcha
Evaluated 5 Dec 2003

Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
Schweizer A, Briand C, Grutter MG
J Biol Chem 2003 Oct 24 278(43):42441-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 23 Sep 2003

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks.
Konishi A, Shimizu S, …, Skoultchi AI, Tsujimoto Y
Cell 2003 Sep 19 114(6):673-88 [abstract on PubMed] [related articles] [order article]
Selected by | Yigong Shi / Shiv Pillai
Evaluated 22 Sep 2003

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.
Arnoult D, Gaume B, …, Cecconi F, Youle RJ
EMBO J 2003 Sep 1 22(17):4385-99 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 22 Sep 2003

HBXIP functions as a cofactor of survivin in apoptosis suppression.
Marusawa H, Matsuzawa S, …, Tamm I, Reed JC
EMBO J 2003 Jun 2 22(11):2729-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 30 Jul 2003

VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Cheng EH, Sheiko TV, …, Craigen WJ, Korsmeyer SJ
Science 2003 Jul 25 301(5632):513-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi / Christoph Borner / Julian Downward / Atan Gross
Evaluated 29 Jul 2003

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.
Yang QH, Church-Hajduk R, …, Newton ML, Du C
Genes Dev 2003 Jun 15 17(12):1487-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 7 Jul 2003

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.
Morén A, Hellman U, …, Heldin CH, Moustakas A
J Biol Chem 2003 Aug 29 278(35):33571-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi / Jenny Ting
Evaluated 7 Jul 2003

Human caspase-7 activity and regulation by its N-terminal peptide.
Denault JB, Salvesen GS
J Biol Chem 2003 Sep 5 278(36):34042-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 7 Jul 2003

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.
Nijhawan D, Fang M, …, Du F, Wang X
Genes Dev 2003 Jun 15 17(12):1475-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sharad Kumar / Yigong Shi
Evaluated 7 Jul 2003

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.
Thompson TB, Woodruff TK, Jardetzky TS
EMBO J 2003 Apr 1 22(7):1555-66 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 30 Apr 2003

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.
Ditzel M, Wilson R, …, Deas E, Meier P
Nat Cell Biol 2003 May 5(5):467-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / William Earnshaw
Evaluated 29 Apr 2003

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
Greenwald J, Groppe J, …, Vale W, Choe S
Mol Cell 2003 Mar 11(3):605-17 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Constam / Yigong Shi
Evaluated 29 Apr 2003

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway.
Jiang X, Kim HE, …, Rosenberg S, Wang X
Science 2003 Jan 10 299(5604):223-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Eui-Ju Choi / Yigong Shi
Evaluated 6 Mar 2003

Reaper is regulated by IAP-mediated ubiquitination.
Olson MR, Holley CL, …, Hay BA, Kornbluth S
J Biol Chem 2003 Feb 7 278(6):4028-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 6 Mar 2003

Insights into the regulatory mechanism for caspase-8 activation.
Donepudi M, Mac Sweeney A, Briand C, Grütter MG
Mol Cell 2003 Feb 11(2):543-9 [abstract on PubMed] [related articles] [order article]
Selected by | Yigong Shi
Evaluated 6 Mar 2003

A unified model for apical caspase activation.
Boatright KM, Renatus M, …, Green DR, Salvesen GS
Mol Cell 2003 Feb 11(2):529-41 [abstract on PubMed] [related articles] [order article]
Selected by | Yigong Shi / Sharad Kumar / Christoph Borner / William Earnshaw
Evaluated 6 Mar 2003

A novel Apaf-1-independent putative caspase-2 activation complex.
Read SH, Baliga BC, …, Vaux DL, Kumar S
J Cell Biol 2002 Dec 9 159(5):739-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Scott Lowe / Yigong Shi
Evaluated 27 Jan 2003

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7.
Tajima Y, Goto K, …, Miyazono K, Imamura T
J Biol Chem 2003 Mar 21 278(12):10716-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 27 Jan 2003

Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP.
Zou H, Yang R, …, Tomaselli KJ, Armstrong RC
J Biol Chem 2003 Mar 7 278(10):8091-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 27 Jan 2003

The harlequin mouse mutation downregulates apoptosis-inducing factor.
Klein JA, Longo-Guess CM, …, Bronson RT, Ackerman SL
Nature 2002 Sep 26 419(6905):367-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Vaux / Sharad Kumar / Yigong Shi / Christoph Borner / Atan Gross
Evaluated 22 Oct 2002

The kinetics of translocation of Smac/DIABLO from the mitochondria to the cytosol in HeLa cells.
Springs SL, Diavolitsis VM, Goodhouse J, McLendon GL
J Biol Chem 2002 Nov 29 277(48):45715-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 22 Oct 2002

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization.
Lassus P, Opitz-Araya X, Lazebnik Y
Science 2002 Aug 23 297(5585):1352-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sharad Kumar / Scott Lowe / Yigong Shi
Evaluated 21 Oct 2002

Stoichiometry of active smad-transcription factor complexes on DNA.
Inman GJ, Hill CS
J Biol Chem 2002 Dec 27 277(52):51008-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 21 Oct 2002

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Marsden VS, O'Connor L, …, Adams JM, Strasser A
Nature 2002 Oct 10 419(6907):634-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharad Kumar / Yigong Shi
Evaluated 21 Oct 2002

DNA binding is required for the apoptogenic action of apoptosis inducing factor.
Ye H, Cande C, …, Kroemer G, Wu H
Nat Struct Biol 2002 Sep 9(9):680-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 21 Oct 2002

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
MacFarlane M, Merrison W, Bratton SB, Cohen GM
J Biol Chem 2002 Sep 27 277(39):36611-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 5 Sep 2002

AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis.
Wu M, Xu LG, …, Zhai Z, Shu HB
J Biol Chem 2002 Jul 12 277(28):25617-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 28 Aug 2002

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.
Fulda S, Wick W, Weller M, Debatin KM
Nat Med 2002 Aug 8(8):808-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 28 Aug 2002

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
Chen CR, Kang Y, Siegel PM, Massagué J
Cell 2002 Jul 12 110(1):19-32 [abstract on PubMed] [related articles] [order article]
Selected by | Yigong Shi
Evaluated 15 Jul 2002

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.
Rao RV, Castro-Obregon S, …, Bredesen DE, Ellerby HM
J Biol Chem 2002 Jun 14 277(24):21836-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yigong Shi
Evaluated 15 Jul 2002

Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark.
Rodriguez A, Chen P, Oliver H, Abrams JM
EMBO J 2002 May 1 21(9):2189-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sharad Kumar / Yigong Shi
Evaluated 15 Jul 2002

The crystal structure of the mouse apoptosis-inducing factor AIF.
Maté MJ, Ortiz-Lombardía M, …, Kroemer G, Alzari PM
Nat Struct Biol 2002 Jun 9(6):442-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi
Evaluated 29 May 2002

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.
Wilson R, Goyal L, …, Steller H, Meier P
Nat Cell Biol 2002 Jun 4(6):445-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yigong Shi / John Abrams
Evaluated 27 May 2002

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Min JH, Yang H, …, Kaelin WG, Pavletich NP
Science 2002 Jun 7 296(5574):1886-9 [abstract on PubMed] [related articles] [FREE full text]