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Wolf Reik
Department of Developmental Genetics, The Babraham Institute, Cambridge, United Kingdom

Faculty Member: GENOMICS & GENETICS > Animal genetics [ since 7 September 2005 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Wolf Reik received his MD from the Universities of Freiburg and Hamburg in Germany. He did his thesis work with Rudolf Jaenisch, and postdoctoral work as an EMBO Fellow with Azim Surani in Cambridge UK. He was a Fellow of the Lister Institute of Preventive Medicine, and is Head of the Laboratory of Developmental Genetics and Imprinting at the Babraham Institute in Cambridge. He headed the Programme of Developmental Genetics at the Babraham Institute, and is currently its Associate Director of Research. He has won a number of prizes and distinctions, including the Wellcome Prize of Physiology. He has served on several national and international academic boards, including the MRC Cross Board Group, and currently CRUK Programmes Committee and BBSRC Strategy Panel. He is an elected member of EMBO and a Fellow of the Academy of Medical Sciences. He is on the executive board of The Epigenome EU Network of Excellence, and on the scientific advisory board of Epigenomics AG Berlin and Seattle. The research interests of his laboratory include mammalian epigenetics, imprinting, developmental genetics, and human genetic diseases.

Home page

http://www.babraham.ac.uk/research/developmental%20genetics/reik/index.htm

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Evaluations

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning.
Cokus SJ, Feng S, …, Pellegrini M, Jacobsen SE
Nature 2008 Mar 13 452(7184):215-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik / Xing Wang Deng / Ulf Pettersson
Evaluated 19 Feb 2008

DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.
Perillo B, Ombra MN, …, Abbondanza C, Avvedimento EV
Science 2008 Jan 11 319(5860):202-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Kaufman / Wolf Reik / Bhaskar Gollapudi / Paola Chiarugi
Evaluated 19 Feb 2008

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Gerken T, Girard CA, …, O'Rahilly S, Schofield CJ
Science 2007 Nov 30 318(5855):1469-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jim Maher / Wolf Reik
Evaluated 19 Feb 2008


Stochastic patterning in the mouse pre-implantation embryo.
Dietrich JE, Hiiragi T
Development 2007 Dec 134(23):4219-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 19 Feb 2008

UHRF1 plays a role in maintaining DNA methylation in mammalian cells.
Bostick M, Kim JK, …, Pradhan S, Jacobsen SE
Science 2007 Sep 21 317(5845):1760-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 9 Nov 2007

A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.
Wood AJ, Roberts RG, …, Schulz R, Oakey RJ
PLoS Genet 2007 Feb 9 3(2):e20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Manyuan Long / Wolf Reik
Evaluated 16 May 2007

Bypassing genomic imprinting allows seed development.
Nowack MK, Shirzadi R, …, Grini PE, Schnittger A
Nature 2007 May 17 447(7142):312-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lieven De Veylder / Wolf Reik / Eric Lam / Joachim Messing
Evaluated 15 May 2007

Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting.
Suzuki S, Ono R, …, Renfree MB, Kaneko-Ishino T
PLoS Genet 2007 Apr 13 3(4):e55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Wolf Reik / Nina Wedell
Evaluated 15 May 2007

DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages.
Maatouk DM, Kellam LD, …, Bartolomei MS, Resnick JL
Development 2006 Sep 133(17):3411-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jane Hubbard / Wolf Reik
Evaluated 8 Jan 2007

PGC7/Stella protects against DNA demethylation in early embryogenesis.
Nakamura T, Arai Y, …, Shiota K, Nakano T
Nat Cell Biol 2007 Jan 9(1):64-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 8 Jan 2007

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Takahashi K, Yamanaka S
Cell 2006 Aug 25 126(4):663-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Graf / Wolf Reik / Raphael Kopan / Charles Coutelle / Charles Brenner
Evaluated 4 Sep 2006


DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation.
Gehring M, Huh JH, …, Goldberg RB, Fischer RL
Cell 2006 Feb 10 124(3):495-506 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik / Vivian Irish / Philip Benfey
Evaluated 1 Mar 2006

Dosage compensation of the active X chromosome in mammals.
Nguyen DK, Disteche CM
Nat Genet 2006 Jan 38(1):47-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 17 Jan 2006

Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs.
Lee N, Maurange C, Ringrose L, Paro R
Nature 2005 Nov 10 438(7065):234-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik / Paul Martin / Norbert Perrimon
Evaluated 28 Nov 2005

The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus.
Loppin B, Bonnefoy E, …, Karr TL, Couble P
Nature 2005 Oct 27 437(7063):1386-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 1 Nov 2005

Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice.
Okamoto I, Arnaud D, …, Avner P, Heard E
Nature 2005 Nov 17 438(7066):369-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 1 Nov 2005

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