PhD: 1976 at McGill
PDF: 1976-80 at UWO
Professor: 1980-1996 at U Alberta, Edmonton
Professor: 1997-present at U Western Ontario, London


Currently:
Co-Director, Biotherapeutics and Immunopathogenesis
at Robarts Research Institute
Co-Founder, VIRON Therapeutics
Canada Research Chair in Molecular Virology

Over 150 scientific publications, and 10 patents
Chair of Virology and Viral Pathogenesis Panel, CIHR

Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Welsch S, Miller S, …, Krijnse-Locker J, Bartenschlager R Cell Host Microbe 2009 Apr 23 5(4):365-75 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Cara Pager and Peter Sarnow / Misha Sherman / Leiliang Zhang and Grant McFadden Evaluated 10 Jun 2009 The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria. Aksyuk AA, Leiman PG, …, Mesyanzhinov VV, Rossmann MG EMBO J 2009 Apr 8 28(7):821-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kim Van Vliet and Grant McFadden Evaluated 8 May 2009 Protection against lethal challenge by Ebola virus-like particles produced in insect cells. Sun Y, Carrion R, …, Compans RW, Yang C Virology 2009 Jan 5 383(1):12-21 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kim Van Vliet and Grant McFadden Evaluated 27 Mar 2009 A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai AW, Benita Y, …, Xavier RJ, Chung RT Cell Host Microbe 2009 Mar 19 5(3):298-307 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Leiliang Zhang and Grant McFadden / Bernardo Mainou and Terence Dermody Evaluated 24 Mar 2009 AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Fernandes-Alnemri T, Yu JW, …, Wu J, Alnemri ES Nature 2009 Jan 21 [abstract on PubMed] [related articles] [full text] Selected by | Leiliang Zhang and Grant McFadden / Christopher Karp Evaluated 11 Feb 2009 Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Kafsack BF, Pena JD, …, Boothroyd JC, Carruthers VB Science 2009 Jan 23 323(5913):530-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Eric Denkers / L. David Sibley / Kim Van Vliet and Grant McFadden / Jean Pieters Evaluated 10 Feb 2009 AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Hornung V, Ablasser A, …, Latz E, Fitzgerald KA Nature 2009 Jan 21 [abstract on PubMed] [related articles] [full text] Selected by | Leiliang Zhang and Grant McFadden / Christopher Karp Evaluated 3 Feb 2009 A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Negishi H, Osawa T, …, Taniguchi T, Honda K Proc Natl Acad Sci U S A 2008 Dec 23 105(51):20446-51 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Leiliang Zhang and Grant McFadden Evaluated 7 Jan 2009 Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases. Soares MM, King SW, Thorpe PE Nat Med 2008 Dec 14(12):1357-1362 [abstract on PubMed] [related articles] [full text] [order article] Selected by | David Leib / Grant McFadden Evaluated 12 Dec 2008 The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation. Zhong B, Yang Y, …, Tien P, Shu HB Immunity 2008 Sep 23 [abstract on PubMed] [related articles] [full text] Selected by | Grant McFadden Evaluated 24 Oct 2008 Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, Barry AP, …, Staprans SI, Feinberg MB Nat Med 2008 Oct 14(10):1077-87 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Xiaojing Ma Evaluated 16 Oct 2008 STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Ishikawa H, Barber GN Nature 2008 Oct 2 455(7213):674-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Bryan Williams / Michael Gale / Grant McFadden / Adolfo Garcia-Sastre Evaluated 10 Oct 2008 Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines. Barnes D, Kunitomi M, …, Saksela K, Andino R Cell Host Microbe 2008 Sep 11 4(3):239-48 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 25 Sep 2008 Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Saito T, Owen DM, …, Marcotrigiano J, Gale M Nature 2008 Jul 24 454(7203):523-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Bryan Williams / Grant McFadden Evaluated 30 Jul 2008 Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition. Tellam J, Smith C, …, Devoy MP, Khanna R Proc Natl Acad Sci U S A 2008 Jul 8 105(27):9319-24 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 24 Jul 2008 Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Mercer J, Helenius A Science 2008 Apr 25 320(5875):531-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 27 May 2008 Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Sun K, Metzger DW Nat Med 2008 May 14(5):558-64 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 12 May 2008 Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Wang Z, Choi MK, …, Nishikura K, Taniguchi T Proc Natl Acad Sci U S A 2008 Mar 28 [abstract on PubMed] [related articles] [full text] Selected by | Grant McFadden Evaluated 9 Apr 2008 The DNA Sugar Backbone 2' Deoxyribose Determines Toll-like Receptor 9 Activation. Haas T, Metzger J, …, Latz E, Wagner H Immunity 2008 Mar 28(3):315-23 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Caetano Reis e Sousa / Grant McFadden Evaluated 28 Mar 2008 An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. Ank N, Iversen MB, …, Klucher K, Paludan SR J Immunol 2008 Feb 15 180(4):2474-85 [abstract on PubMed] [related articles] [order article] Selected by | Grant McFadden Evaluated 13 Mar 2008 Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Asagiri M, Hirai T, …, Saftig P, Takayanagi H Science 2008 Feb 1 319(5863):624-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Colin Watts / Robert Booth / Lionel Ivashkiv Evaluated 5 Feb 2008 NLRX1 is a regulator of mitochondrial antiviral immunity. Moore CB, Bergstralh DT, …, Chen Z, Ting JP Nature 2008 Jan 31 451(7178):573-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Michael Gale / Torben Lund / Christopher Karp Evaluated 4 Feb 2008 TAM receptors are pleiotropic inhibitors of the innate immune response. Rothlin CV, Ghosh S, …, Oldstone MB, Lemke G Cell 2007 Dec 14 131(6):1124-36 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Anthony DeFranco / David Alpers Evaluated 20 Dec 2007 Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Frias-Staheli N, Giannakopoulos NV, …, García-Sastre A, Virgin HW Cell Host Microbe 2007 Dec 13 2(6):404-16 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 20 Dec 2007 Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. Loo YM, Fornek J, …, Katze MG, Gale M J Virol 2008 Jan 82(1):335-45 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 18 Dec 2007 Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Rawson PM, Molette C, …, Sette A, Barnaba V Nat Med 2007 Dec 13(12):1431-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Sarah Rowland-Jones Evaluated 14 Dec 2007 DUBA: a deubiquitinase that regulates type I interferon production. Kayagaki N, Phung Q, …, Arnott D, Dixit VM Science 2007 Dec 7 318(5856):1628-32 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Bryan Williams Evaluated 14 Dec 2007 TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Ferwerda B, McCall MB, …, van der Meer JW, Netea MG Proc Natl Acad Sci U S A 2007 104:16645-50 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Jerrold Weiss Evaluated 23 Oct 2007 Small self-RNA generated by RNase L amplifies antiviral innate immunity. Malathi K, Dong B, Gale M, Silverman RH Nature 2007 Aug 16 448(7155):816-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Caetano Reis e Sousa / Bryan Williams / David Leib / Philippe Pierre / Grant McFadden Evaluated 23 Oct 2007 Characterization of reemerging chikungunya virus. Sourisseau M, Schilte C, …, Albert ML, Schwartz O PLoS Pathog 2007 Jun 3(6):e89 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 22 Oct 2007 TLR3 deficiency in patients with herpes simplex encephalitis. Zhang SY, Jouanguy E, …, Abel L, Casanova JL Science 2007 Sep 14 317(5844):1522-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Brigitte Huber / Grant McFadden Evaluated 20 Sep 2007 "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics. Stebbings R, Findlay L, …, Thorpe R, Poole S J Immunol 2007 Sep 1 179(5):3325-31 [abstract on PubMed] [related articles] [order article] Selected by | Grant McFadden Evaluated 24 Aug 2007 Poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals. Piskurek O, Okada N Proc Natl Acad Sci U S A 2007 Jul 17 104(29):12046-51 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 3 Aug 2007 DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Takaoka A, Wang Z, …, Ohba Y, Taniguchi T Nature 2007 Jul 26 448(7152):501-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Alan Houghton / Grant McFadden / David Underhill Evaluated 3 Aug 2007 Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Chen CJ, Kono H, …, Akira S, Rock KL Nat Med 2007 Jul 13(7):851-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | David Kranz / Grant McFadden / Klaus Ley Evaluated 17 Jul 2007 A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans. Chua KB, Crameri G, …, Eaton BT, Wang LF Proc Natl Acad Sci U S A 2007 Jul 3 104(27):11424-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 17 Jul 2007 Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein. Kaiser SM, Malik HS, Emerman M Science 2007 Jun 22 316(5832):1756-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Philip Tsichlis / Vincent Ling Evaluated 4 Jul 2007 Small-molecule activators of RNase L with broad-spectrum antiviral activity. Thakur CS, Jha BK, …, Gudkov A, Silverman RH Proc Natl Acad Sci U S A 2007 Jun 5 104(23):9585-90 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 15 Jun 2007 The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Zhao T, Yang L, …, Hiscott J, Lin R Nat Immunol 2007 Jun 8(6):592-600 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 15 Jun 2007 Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Cheng G, Zhong J, Chung J, Chisari FV Proc Natl Acad Sci U S A 2007 May 22 104(21):9035-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 15 Jun 2007 Herpesvirus latency confers symbiotic protection from bacterial infection. Barton ES, White DW, …, Miller VL, Virgin HW Nature 2007 May 17 447(7142):326-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Miguel Valvano / Marcia Blackman / Grant McFadden / Marc Lecuit / Jean Pieters / W. Ian Lipkin Evaluated 23 May 2007 Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Arimoto K, Takahashi H, …, Fujita T, Shimotohno K Proc Natl Acad Sci U S A 2007 May 1 104(18):7500-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 4 May 2007 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Gack MU, Shin YC, …, Inoue S, Jung JU Nature 2007 Apr 19 446(7138):916-920 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Astar Winoto Evaluated 23 Apr 2007 Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha. Hurgin V, Novick D, …, Dinarello CA, Rubinstein M Proc Natl Acad Sci U S A 2007 Mar 20 104(12):5044-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 27 Mar 2007 Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Faustin B, Lartigue L, …, Rouiller I, Reed JC Mol Cell 2007 Mar 9 25(5):713-24 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 22 Mar 2007 The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP. Monné M, Robinson AJ, …, Fearnley IM, Kunji ER J Virol 2007 Apr 81(7):3181-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Eduardo Rial / Chantal Abergel / Grant McFadden / Lynn Enquist Evaluated 22 Mar 2007 Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression. Parrish S, Resch W, Moss B Proc Natl Acad Sci U S A 2007 Feb 13 104(7):2139-44 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 21 Feb 2007 MicroRNA-155 is induced during the macrophage inflammatory response. O'Connell RM, Taganov KD, …, Cheng G, Baltimore D Proc Natl Acad Sci U S A 2007 Jan 30 104(5):1604-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Fritz Eckstein Evaluated 12 Feb 2007 IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Lenschow DJ, Lai C, …, Horak I, Virgin HW Proc Natl Acad Sci U S A 2007 Jan 23 104(4):1371-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Robert Krug / Richard Kuhn Evaluated 29 Jan 2007 Antibiotics as intermicrobial signaling agents instead of weapons. Linares JF, Gustafsson I, Baquero F, Martinez JL Proc Natl Acad Sci U S A 2006 Dec 19 103(51):19484-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Beth Lazazzera / Grant McFadden / David Payne Evaluated 3 Jan 2007 Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis. Zaragoza C, Saura M, …, Lamas S, Lowenstein CJ Proc Natl Acad Sci U S A 2006 Dec 12 103(50):19051-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 2 Jan 2007 An essential role for Akt1 in dendritic cell function and tumor immunotherapy. Park D, Lapteva N, …, Slawin KM, Spencer DM Nat Biotechnol 2006 Dec 24(12):1581-90 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 2 Jan 2007 On the definition of a criterion of immunogenicity. Pradeu T, Carosella ED Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17858-61 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 5 Dec 2006 Herpes simplex virus encephalitis in human UNC-93B deficiency. Casrouge A, Zhang SY, …, Abel L, Casanova JL Science 2006 Oct 13 314(5797):308-12 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patrick S. Moore / Marco Colonna / Peter Van Endert / Grant McFadden Evaluated 19 Oct 2006 Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant. Andreakos E, Williams RO, …, Foxwell BM, Feldmann M Proc Natl Acad Sci U S A 2006 Sep 26 103(39):14459-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Angela Vincent Evaluated 6 Oct 2006 Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Gurcel L, Abrami L, …, Tschopp J, van der Goot FG Cell 2006 Sep 22 126(6):1135-45 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Robert Parton Evaluated 6 Oct 2006 A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis. Trapp S, Parcells MS, …, Nair VK, Osterrieder N J Exp Med 2006 May 15 203(5):1307-17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 9 May 2006 Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. Weber F, Wagner V, …, Hartmann R, Paludan SR J Virol 2006 May 80(10):5059-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Lynn Enquist / Grant McFadden Evaluated 5 May 2006 Building a virus from scratch: assembly of an infectious virus using purified components in a rigorously defined biochemical assay system. Gaussier H, Yang Q, Catalano CE J Mol Biol 2006 Apr 7 357(4):1154-66 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 2 May 2006 Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. Berlanga JJ, Ventoso I, …, Carrasco L, de Haro C EMBO J 2006 Apr 19 25(8):1730-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 28 Apr 2006 A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus. Alejo A, Ruiz-Argüello MB, …, Saraiva M, Alcami A Proc Natl Acad Sci U S A 2006 Apr 11 103(15):5995-6000 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 28 Apr 2006 Restoring function in exhausted CD8 T cells during chronic viral infection. Barber DL, Wherry EJ, …, Freeman GJ, Ahmed R Nature 2006 Feb 9 439(7077):682-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Barry Rouse / Etienne Joly / Christian Engwerda / Nicholas Restifo / Allan Zajac / Linda Bradley / Jonathan Green / Lieping Chen / Luis J. Montaner / Arthur Hurwitz / Grant McFadden / Matthias von Herrath / Scott Gray-Owen Evaluated 13 Mar 2006 Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Coyne CB, Bergelson JM Cell 2006 Jan 13 124(1):119-31 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Marc Lecuit / Armando De Palma and Johan Neyts Evaluated 25 Jan 2006 Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Stetson DB, Medzhitov R Immunity 2006 Jan 24(1):93-103 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Kathryn Calame Evaluated 24 Jan 2006 A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Ishii KJ, Coban C, …, Takeuchi O, Akira S Nat Immunol 2006 Jan 7(1):40-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Caetano Reis e Sousa / Grant McFadden Evaluated 24 Jan 2006 A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Janes KA, Albeck JG, …, Lauffenburger DA, Yaffe MB Science 2005 Dec 9 310(5754):1646-53 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Hans van Beek / Andrius Kazlauskas Evaluated 14 Dec 2005 Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Li XD, Sun L, …, Pineda G, Chen ZJ Proc Natl Acad Sci U S A 2005 Dec 6 102(49):17717-22 [abstract on PubMed] [related articles] [FREE full text] Selected by | Jim Smiley / Grant McFadden / Rino Rappuoli Evaluated 13 Dec 2005 Disruption of MHC class II-restricted antigen presentation by vaccinia virus. Li P, Wang N, …, Brutkiewicz RR, Blum JS J Immunol 2005 Nov 15 175(10):6481-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 11 Nov 2005 The seven dirty little secrets of major histocompatibility complex class I antigen processing. Yewdell JW Immunol Rev 2005 Oct 207:8-18 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 14 Oct 2005 The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. Rothenfusser S, Goutagny N, …, Akira S, Fitzgerald KA J Immunol 2005 Oct 15 175(8):5260-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 13 Oct 2005 Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Tumpey TM, Basler CF, …, Palese P, García-Sastre A Science 2005 Oct 7 310(5745):77-80 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Rino Rappuoli Evaluated 12 Oct 2005 Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10. Maloney G, Schröder M, Bowie AG J Biol Chem 2005 Sep 2 280(35):30838-44 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 2 Sep 2005 Virology: independent virus development outside a host. Häring M, Vestergaard G, …, Garrett RA, Prangishvili D Nature 2005 Aug 25 436(7054):1101-2 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 1 Sep 2005 The product of the vaccinia virus L5R gene is a fourth membrane protein encoded by all poxviruses that is required for cell entry and cell-cell fusion. Townsley AC, Senkevich TG, Moss B J Virol 2005 Sep 79(17):10988-98 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 19 Aug 2005 Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor. Chahroudi A, Chavan R, …, Silvestri G, Feinberg MB J Virol 2005 Aug 79(16):10397-407 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 8 Aug 2005 Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication. Mannová P, Beretta L J Virol 2005 Jul 79(14):8742-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 12 Jul 2005 Resistance to viral infection of super p53 mice. Munoz-Fontela C, Angel Garcia M, …, Serrano M, Rivas C Oncogene 2005 Feb 14 [abstract on PubMed] [related articles] [full text] Selected by | Grant McFadden Evaluated 27 May 2005 RNA silencing: a remarkable parallel to protein-based immune systems in vertebrates? Chen W, Liu M, …, Fei L, Zheng Z FEBS Lett 2005 Apr 25 579(11):2267-72 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 27 May 2005 Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential. Wollmann G, Tattersall P, van den Pol AN J Virol 2005 May 79(10):6005-22 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 9 May 2005 Vaccinia virus H2 protein is an essential component of a complex involved in virus entry and cell-cell fusion. Senkevich TG, Moss B J Virol 2005 Apr 79(8):4744-54 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 6 Apr 2005 Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. O'Shea C, Klupsch K, …, McCormick F, Stokoe D EMBO J 2005 Mar 23 24(6):1211-21 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 6 Apr 2005 Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation. McCoy SL, Kurtz SE, …, Trune DR, Hefeneider SH J Immunol 2005 Mar 1 174(5):3006-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 4 Mar 2005 Does common architecture reveal a viral lineage spanning all three domains of life? Benson SD, Bamford JK, Bamford DH, Burnett RM Mol Cell 2004 Dec 3 16(5):673-85 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden Evaluated 26 Jan 2005 Vaccinia virus penetration requires cholesterol and results in specific viral envelope proteins associated with lipid rafts. Chung CS, Huang CY, Chang W J Virol 2005 Feb 79(3):1623-34 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 24 Jan 2005 Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Wang T, Town T, …, Fikrig E, Flavell RA Nat Med 2004 Dec 10(12):1366-73 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Barry Rouse Evaluated 10 Dec 2004 Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. Meads MB, Medveczky PG J Biol Chem 2004 Dec 10 279(50):51793-803 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 10 Dec 2004 The acquired immune system: a vantage from beneath. Hedrick SM Immunity 2004 Nov 21(5):607-15 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Eric Brown / Emanuela Handman / John Mansfield / Peter Openshaw / Ann Hill Evaluated 23 Nov 2004 Modified vaccinia virus Ankara immunization protects against lethal challenge with recombinant vaccinia virus expressing murine interleukin-4. McCurdy LH, Rutigliano JA, …, Chen M, Graham BS J Virol 2004 Nov 78(22):12471-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 9 Nov 2004 Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response. Abate DA, Watanabe S, Mocarski ES J Virol 2004 Oct 78(20):10995-1006 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 9 Nov 2004 Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets. Weingartl H, Czub M, …, Manning L, Cao J J Virol 2004 Nov 78(22):12672-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 5 Nov 2004 Tropism illuminated: lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system. von Messling V, Milosevic D, Cattaneo R Proc Natl Acad Sci U S A 2004 Sep 28 101(39):14216-21 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 1 Oct 2004 Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies. Kim M, Yang H, …, Welsh RM, Reinherz EL J Biol Chem 2004 Jun 11 279(24):25838-48 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 26 Aug 2004 Phospholipid scramblase 1 potentiates the antiviral activity of interferon. Dong B, Zhou Q, …, Sims PJ, Silverman RH J Virol 2004 Sep 78(17):8983-93 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 18 Aug 2004 Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Chang HM, Paulson M, …, Marié I, Levy DE Proc Natl Acad Sci U S A 2004 Jun 29 101(26):9578-83 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 8 Jul 2004 The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Yoneyama M, Kikuchi M, …, Akira S, Fujita T Nat Immunol 2004 Jul 5(7):730-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Caetano Reis e Sousa Evaluated 2 Jul 2004 Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. Perry AK, Chow EK, …, Yeh WC, Cheng G J Exp Med 2004 Jun 21 199(12):1651-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 2 Jul 2004 The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. Hemmi H, Takeuchi O, …, Takeda K, Akira S J Exp Med 2004 Jun 21 199(12):1641-50 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 2 Jul 2004 Cellular and humoral immunity against vaccinia virus infection of mice. Xu R, Johnson AJ, Liggitt D, Bevan MJ J Immunol 2004 May 15 172(10):6265-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 13 May 2004 Does Toll-like receptor 3 play a biological role in virus infections? Edelmann KH, Richardson-Burns S, …, Flavell RA, Oldstone MB Virology 2004 May 1 322(2):231-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Grant McFadden / Robert Krug Evaluated 11 May 2004 Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge. Wyatt LS, Earl PL, Eller LA, Moss B Proc Natl Acad Sci U S A 2004 Mar 11 [abstract on PubMed] [related articles] Selected by | Grant McFadden Evaluated 22 Mar 2004 The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation. Shisler JL, Jin XL J Virol 2004 Apr 78(7):3553-60 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 22 Mar 2004 Vaccinia virus entry into cells is dependent on a virion surface protein encoded by the A28L gene. Senkevich TG, Ward BM, Moss B J Virol 2004 Mar 78(5):2357-66 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 23 Feb 2004 Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Li WX, Li H, …, Palese P, Ding SW Proc Natl Acad Sci U S A 2004 Feb 3 101(5):1350-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Andy Maule / Daniel Gallie Evaluated 12 Feb 2004 Innate cellular response to virus particle entry requires IRF3 but not virus replication. Collins SE, Noyce RS, Mossman KL J Virol 2004 Feb 78(4):1706-17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 6 Feb 2004 IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. McWhirter SM, Fitzgerald KA, …, Golenbock DT, Maniatis T Proc Natl Acad Sci U S A 2004 Jan 6 101(1):233-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Jim Smiley / Grant McFadden Evaluated 6 Feb 2004 Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1. Najarro P, Lee HJ, …, Pease J, Smith GL J Gen Virol 2003 Dec 84(Pt 12):3325-36 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 12 Dec 2003 Evaluating plague and smallpox as historical selective pressures for the CCR5-Delta 32 HIV-resistance allele. Galvani AP, Slatkin M Proc Natl Acad Sci U S A 2003 Dec 9 100(25):15276-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Thomas Mitchell-Olds Evaluated 12 Dec 2003 Mutations in the vaccinia virus A33R and B5R envelope proteins that enhance release of extracellular virions and eliminate formation of actin-containing microvilli without preventing tyrosine phosphorylation of the A36R protein. Katz E, Ward BM, Weisberg AS, Moss B J Virol 2003 Nov 77(22):12266-75 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 26 Nov 2003 Poxvirus DNA topoisomerase knockout mutant exhibits decreased infectivity associated with reduced early transcription. Da Fonseca F, Moss B Proc Natl Acad Sci U S A 2003 Sep 30 100(20):11291-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 7 Oct 2003 Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens. Wise LM, Ueda N, …, Stacker SA, Mercer AA J Biol Chem 2003 Sep 26 278(39):38004-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 24 Sep 2003 Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infection. Reading PC, Moore JB, Smith GL J Exp Med 2003 May 19 197(10):1269-78 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 26 Jun 2003 Cellular gene expression survey of vaccinia virus infection of human HeLa cells. Guerra S, López-Fernández LA, …, Harshman K, Esteban M J Virol 2003 Jun 77(11):6493-506 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 5 Jun 2003 Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Foy E, Li K, …, Lemon SM, Gale M Science 2003 May 16 300(5622):1145-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 5 Jun 2003 Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes. van Dyk LF, Virgin HW, Speck SH J Virol 2003 May 77(9):5118-26 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 25 Apr 2003 The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. Harte MT, Haga IR, …, Bowie A, O'Neill LA J Exp Med 2003 Feb 3 197(3):343-51 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Steve Ward / Emanuela Handman Evaluated 14 Feb 2003 Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins. Bryant NA, Davis-Poynter N, Vanderplasschen A, Alcami A EMBO J 2003 Feb 17 22(4):833-46 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Rino Rappuoli Evaluated 14 Feb 2003 Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. Xiang Y, Moss B J Virol 2003 Feb 77(4):2623-30 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 31 Jan 2003 Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity. Naranatt PP, Akula SM, …, Krishnan HH, Chandran B J Virol 2003 Jan 77(2):1524-39 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 23 Jan 2003 Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines. Drexler I, Staib C, …, Erfle V, Sutter G Proc Natl Acad Sci U S A 2003 Jan 7 100(1):217-22 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / Kendall Smith Evaluated 23 Jan 2003 Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. Feng P, Park J, …, Bram RJ, Jung JU J Virol 2002 Nov 76(22):11491-504 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 28 Oct 2002 Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx. Li XD, Mäkelä TP, …, Vaheri A, Lankinen H J Gen Virol 2002 Apr 83(Pt 4):759-66 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 23 Oct 2002 Immunogenicity and safety of defective vaccinia virus lister: comparison with modified vaccinia virus Ankara. Ober BT, Brühl P, …, Gerencer M, Falkner FG J Virol 2002 Aug 76(15):7713-23 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 18 Oct 2002 Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins. Bellows DS, Howell M, …, Hazlewood SA, Hardwick JM J Virol 2002 Mar 76(5):2469-79 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 18 Oct 2002 Cloning the vaccinia virus genome as a bacterial artificial chromosome in Escherichia coli and recovery of infectious virus in mammalian cells. Domi A, Moss B Proc Natl Acad Sci U S A 2002 Sep 17 99(19):12415-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 20 Sep 2002 The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis. Filippova M, Song H, …, Dermody TS, Duerksen-Hughes PJ J Biol Chem 2002 Jun 14 277(24):21730-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 26 Jul 2002 Variola virus immune evasion design: expression of a highly efficient inhibitor of human complement. Rosengard AM, Liu Y, Nie Z, Jimenez R Proc Natl Acad Sci U S A 2002 Jun 25 99(13):8808-13 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden / John Atkinson Evaluated 26 Jun 2002 Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. Panus JF, Smith CA, …, Patel DD, Pickup DJ Proc Natl Acad Sci U S A 2002 Jun 11 99(12):8348-53 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 14 Jun 2002 Identification of the in vivo role of a viral bcl-2. Gangappa S, van Dyk LF, …, Speck SH, Virgin HW J Exp Med 2002 Apr 1 195(7):931-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 31 May 2002 Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Huang Q, Petros AM, …, Fesik SW, Olejniczak ET Proc Natl Acad Sci U S A 2002 Mar 19 99(6):3428-33 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 19 Apr 2002 A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Zhu FX, King SM, …, Levy DE, Yuan Y Proc Natl Acad Sci U S A 2002 Apr 16 99(8):5573-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 19 Apr 2002 Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins. Guerin JL, Gelfi J, …, Sutter G, Messud-Petit F J Virol 2002 Mar 76(6):2912-23 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 1 Mar 2002 Human monkeypox and smallpox viruses: genomic comparison. Shchelkunov SN, Totmenin AV, …, Moss B, Sandakhchiev LS FEBS Lett 2001 Nov 30 509(1):66-70 [abstract on PubMed] [related articles] [order article] Selected by | Grant McFadden Evaluated 22 Jan 2002 A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication. de Magalhães JC, Andrade AA, …, Gazzinelli RT, Bonjardim CA J Biol Chem 2001 Oct 19 276(42):38353-60 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 20 Dec 2001 Murine cytomegalovirus M78 protein, a G protein-coupled receptor homologue, is a constituent of the virion and facilitates accumulation of immediate-early viral mRNA. Oliveira SA, Shenk TE Proc Natl Acad Sci U S A 2001 Mar 13 98(6):3237-42 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 10 Oct 2001 Determination of the functional epitopes of human interleukin-18-binding protein by site-directed mutagenesis. Xiang Y, Moss B J Biol Chem 2001 May 18 276(20):17380-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Grant McFadden Evaluated 10 Oct 2001

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