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Takashi Tsuruo
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan

Faculty Member: PHARMACOLOGY & DRUG DISCOVERY > Cancer therapeutics [ since 2 May 2006 ]
[ Evaluations ]
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Evaluations

A bistable Rb-E2F switch underlies the restriction point.
Yao G, Lee TJ, …, Nevins JR, You L
Nat Cell Biol 2008 Apr 10(4):476-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo / Ron Prywes
Evaluated 8 May 2008

Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs.
Morimoto K, Satoh-Yamaguchi K, …, Takai Y, Imai T
Oncogene 2008 Jan 10 27(3):264-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 4 Mar 2008

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation.
Lin X, David CA, …, Fesik SW, Shen Y
Proc Natl Acad Sci U S A 2008 Jan 8 105(1):174-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Takashi Tsuruo
Evaluated 7 Feb 2008

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells.
Shi XB, Xue L, …, Kung HJ, deVere White RW
Proc Natl Acad Sci U S A 2007 Dec 11 104(50):19983-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 15 Jan 2008

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Berns K, Horlings HM, …, van de Vijver MJ, Bernards R
Cancer Cell 2007 Oct 12(4):395-402 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 12 Dec 2007

Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
Cordenonsi M, Montagner M, …, Dupont S, Piccolo S
Science 2007 Feb 9 315(5813):840-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Weber / Kermit Carraway / Andrius Kazlauskas / Takashi Tsuruo
Evaluated 5 Nov 2007

Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis.
Sun MG, Williams J, …, Green DR, Frey TG
Nat Cell Biol 2007 Sep 9(9):1057-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Youle / Takashi Tsuruo
Evaluated 3 Oct 2007

Global changes to the ubiquitin system in Huntington's disease.
Bennett EJ, Shaler TA, …, Schulman H, Kopito RR
Nature 2007 Aug 9 448(7154):704-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Allan Tobin / Ulrich Hartl / Sharad Kumar / Takashi Tsuruo
Evaluated 11 Sep 2007

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, …, Krystal GW, Chiosis G
Nat Chem Biol 2007 Aug 3(8):498-507 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo / Takashi Tsuruo
Evaluated 2 Aug 2007

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
Swanton C, Marani M, …, Downward J, Nicke B
Cancer Cell 2007 Jun 11(6):498-512 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Abraham / Takashi Tsuruo / Giulio Superti-Furga / Gerrit van Meer
Evaluated 3 Jul 2007

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.
Gupta GP, Nguyen DX, …, Manova-Todorova K, Massagué J
Nature 2007 Apr 12 446(7137):765-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ross Cagan / Takashi Tsuruo
Evaluated 6 Jun 2007

Synthetic lethal screen identification of chemosensitizer loci in cancer cells.
Whitehurst AW, Bodemann BO, …, Xie XJ, White MA
Nature 2007 Apr 12 446(7137):815-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo / Takashi Tsuruo
Evaluated 8 May 2007

Molecular definition of breast tumor heterogeneity.
Shipitsin M, Campbell LL, …, Gelman RS, Polyak K
Cancer Cell 2007 Mar 11(3):259-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo / Matthew John Smalley / Albert Deisseroth
Evaluated 29 Mar 2007

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
Yamasaki S, Yagishita N, …, Tanaka K, Nakajima T
EMBO J 2007 Jan 10 26(1):113-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 5 Mar 2007

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.
Poole AJ, Li Y, …, Lee WH, Lee EY
Science 2006 Dec 1 314(5804):1467-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Takashi Tsuruo / Charles Streuli
Evaluated 1 Feb 2007


Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism.
Pelicano H, Xu RH, …, Plunkett W, Huang P
J Cell Biol 2006 Dec 18 175(6):913-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Wipf / Takashi Tsuruo
Evaluated 11 Jan 2007

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.
O'Brien CA, Pollett A, Gallinger S, Dick JE
Nature 2007 Jan 4 445(7123):106-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo / Matthew John Smalley / Silvana Curci / Thomas Ried / Ulf Pettersson / Albert Deisseroth
Evaluated 7 Dec 2006

Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression.
Bandyopadhyay S, Zhan R, …, Furuta E, Watabe K
Nat Med 2006-08-01 12(8):933-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 14 Nov 2006

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression.
Christophorou MA, Ringshausen I, …, Swigart LB, Evan GI
Nature 2006 Sep 14 443(7108):214-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo / John Abrams / Frank de Gruijl
Evaluated 2 Oct 2006

Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase.
Jin H, Sperka T, Herrlich P, Morrison H
Nature 2006 Aug 3 442(7102):576-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 25 Aug 2006

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
Fantin VR, St-Pierre J, Leder P
Cancer Cell 2006 Jun 9(6):425-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo
Evaluated 3 Aug 2006

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.
Grimm D, Streetz KL, …, Salazar F, Kay MA
Nature 2006 May 25 441(7092):537-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takashi Tsuruo / William H. Colledge
Evaluated 28 Jun 2006

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
Yaguchi S, Fukui Y, …, Yamazaki K, Yamori T
J Natl Cancer Inst 2006 Apr 19 98(8):545-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Takashi Tsuruo
Evaluated 7 Jun 2006

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