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Fritz Eckstein
Abteilung Chemie, Max Planck Institute for Experimental Medicine, Germany

Faculty Member: CHEMICAL BIOLOGY > Directed molecular evolution [ since 22 August 2003 ]
[ Sponsorship ] [ Evaluations ]
Sponsorship

Fritz Eckstein sponsors free access to F1000 for Amrita Vishwa VidyaPeetham, India. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

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Evaluations

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.
Tam OH, Aravin AA, …, Schultz RM, Hannon GJ
Nature 2008 Apr 10 [abstract on PubMed] [related articles] [full text]
Selected by | Fritz Eckstein
Evaluated 21 Apr 2008

Selective Blockade of MicroRNA Processing by Lin-28.
Viswanathan SR, Daley GQ, Gregory RI
Science 2008 Feb 21 [abstract on PubMed] [related articles] [full text]
Selected by | Fritz Eckstein
Evaluated 20 Mar 2008

A chemical method for fast and sensitive detection of DNA synthesis in vivo.
Salic A, Mitchison TJ
Proc Natl Acad Sci U S A 2008 Feb 19 105(7):2415-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andy Groves / Fritz Eckstein / Ken Irvine / Stephen Kearsey / Lucio Comai
Evaluated 25 Feb 2008

Identification of host proteins required for HIV infection through a functional genomic screen.
Brass AL, Dykxhoorn DM, …, Lieberman J, Elledge SJ
Science 2008 Feb 15 319(5865):921-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / James Crowe / Alan Landay / Winston Hide
Evaluated 16 Jan 2008


Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
Hanna J, Wernig M, …, Townes TM, Jaenisch R
Science 2007 Dec 21 318(5858):1920-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William H. Colledge / Fritz Eckstein / Ali H. Brivanlou
Evaluated 11 Jan 2008


Phosphorothioation of DNA in bacteria by dnd genes.
Wang L, Chen S, …, Deng Z, Dedon PC
Nat Chem Biol 2007 Nov 3(11):709-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Marc Fontecave / Anthony Czarnik
Evaluated 31 Oct 2007

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
Till S, Lejeune E, …, Hentze MW, Ladurner AG
Nat Struct Mol Biol 2007 Oct 14(10):897-903 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 8 Oct 2007

Nucleoside alpha-thiotriphosphates, polymerases and the exonuclease III analysis of oligonucleotides containing phosphorothioate linkages.
Yang Z, Sismour AM, Benner SA
Nucleic Acids Res 2007 35(9):3118-27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 6 Aug 2007

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.
Thermann R, Hentze MW
Nature 2007 Jun 14 447(7146):875-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Kiebler / Richard Maraia / Matthew Sachs / Peter Sarnow / Fritz Eckstein / Samuel Gunderson / Richard Carthew
Evaluated 21 Jun 2007

Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins.
Fahmi NE, Dedkova L, …, Golovine S, Hecht SM
J Am Chem Soc 2007 Mar 28 129(12):3586-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 8 May 2007

Suppression of microRNA-silencing pathway by HIV-1 during virus replication.
Triboulet R, Mari B, …, Jeang KT, Benkirane M
Science 2007 Mar 16 315(5818):1579-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Michael Kiebler
Evaluated 6 Mar 2007

MicroRNA-155 is induced during the macrophage inflammatory response.
O'Connell RM, Taganov KD, …, Cheng G, Baltimore D
Proc Natl Acad Sci U S A 2007 Jan 30 104(5):1604-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Grant McFadden / Fritz Eckstein
Evaluated 2 Mar 2007

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance.
Hafner M, Schmitz A, …, Bauer I, Famulok M
Nature 2006 Dec 14 444(7121):941-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Catherine Jackson / Fritz Eckstein / Andres Jaschke
Evaluated 22 Dec 2006

Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities.
Horhota AT, Szostak JW, McLaughlin LW
Org Lett 2006 Nov 9 8(23):5345-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 10 Nov 2006

L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells.
Yang N, Kazazian HH
Nat Struct Mol Biol 2006 Sep 13(9):763-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 20 Sep 2006

Tertiary contacts distant from the active site prime a ribozyme for catalysis.
Martick M, Scott WG
Cell 2006 Jul 28 126(2):309-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Sabine Müller / Eric Westhof
Evaluated 1 Aug 2006

Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.
Gupta A, Gartner JJ, …, Hatzigeorgiou AG, Fraser NW
Nature 2006 Jul 6 442(7098):82-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Sarnow / Bino John / Michael Kiebler / Fritz Eckstein / Ulf Pettersson
Evaluated 26 Jul 2006

Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer.
Brown BD, Venneri MA, …, Sergi Sergi L, Naldini L
Nat Med 2006 May 12(5):585-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Mark Kay
Evaluated 11 Jul 2006


siRNA in human cells selectively localizes to target RNA sites.
Berezhna SY, Supekova L, …, Schultz PG, Deniz AA
Proc Natl Acad Sci U S A 2006 May 16 103(20):7682-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 23 May 2006

Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs.
Giraldez AJ, Mishima Y, …, Enright AJ, Schier AF
Science 2006 Apr 7 312(5770):75-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John / Elsebet Lund / Ivor Mason / Fritz Eckstein / Roger Patient
Evaluated 19 Apr 2006

RNAi-mediated gene silencing in non-human primates.
Zimmermann TS, Lee AC, …, Vornlocher HP, MacLachlan I
Nature 2006 May 4 441(7089):111-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / John Nemunaitis
Evaluated 30 Mar 2006

A brain-specific microRNA regulates dendritic spine development.
Schratt GM, Tuebing F, …, Kiebler M, Greenberg ME
Nature 2006 Jan 19 439(7074):283-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karl-Peter Giese / Harukazu Nakamura / Allan Tobin / Fritz Eckstein / Alain Prochiantz
Evaluated 2 Mar 2006

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases.
Yang W, Chendrimada TP, …, Shiekhattar R, Nishikura K
Nat Struct Mol Biol 2006 Jan 13(1):13-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 11 Jan 2006

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution.
Farh KK, Grimson A, …, Burge CB, Bartel DP
Science 2005 Dec 16 310(5755):1817-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John / Phillip Zamore / Fritz Eckstein / Stephen Holbrook
Evaluated 20 Dec 2005

Silencing of microRNAs in vivo with 'antagomirs'.
Krützfeldt J, Rajewsky N, …, Manoharan M, Stoffel M
Nature 2005 Dec 1 438(7068):685-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Peter Sarnow
Evaluated 8 Nov 2005

miR-15 and miR-16 induce apoptosis by targeting BCL2.
Cimmino A, Calin GA, …, Negrini M, Croce CM
Proc Natl Acad Sci U S A 2005 Sep 27 102(39):13944-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 7 Oct 2005

Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids.
Janowski BA, Kaihatsu K, …, Mendelson CR, Corey DR
Nat Chem Biol 2005 Sep 1(4):210-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carlos F. Barbas / Fritz Eckstein
Evaluated 1 Sep 2005

Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development.
Leaman D, Chen PY, …, Tuschl T, Gaul U
Cell 2005 Jul 1 121(7):1097-108 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Detlef Weigel / Ken Irvine / Thomas Lecuit
Evaluated 5 Jul 2005

MicroRNA expression profiles classify human cancers.
Lu J, Getz G, …, Horvitz HR, Golub TR
Nature 2005 Jun 9 435(7043):834-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Julie Ahringer / Frank Lyko / Fritz Eckstein / Charles Auffray / Miles Wilkinson
Evaluated 23 Jun 2005

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.
Song E, Zhu P, …, Marasco WA, Lieberman J
Nat Biotechnol 2005 Jun 23(6):709-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 31 May 2005

A cellular microRNA mediates antiviral defense in human cells.
Lecellier CH, Dunoyer P, …, Saïb A, Voinnet O
Science 2005 Apr 22 308(5721):557-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jim Smiley / Fritz Eckstein / Andy Maule
Evaluated 3 May 2005

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.
Ralph GS, Radcliffe PA, …, Mazarakis ND, Azzouz M
Nat Med 2005 Apr 11(4):429-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 31 Mar 2005

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs.
Lim LP, Lau NC, …, Linsley PS, Johnson JM
Nature 2005 Feb 17 433(7027):769-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Isaac Kohane / Harukazu Nakamura / Fritz Eckstein / Ulf Pettersson / Andrew D. Sharrocks / Detlef Weigel / Richard Carthew / Alejandro Sanchez-Alvarado / Vishvanath Nene / Miles Wilkinson
Evaluated 28 Feb 2005

SIRT1 regulates HIV transcription via Tat deacetylation.
Pagans S, Pedal A, …, Verdin E, Ott M
PLoS Biol 2005 Feb 3(2):e41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 22 Feb 2005

Inhibition of respiratory viruses by nasally administered siRNA.
Bitko V, Musiyenko A, Shulyayeva O, Barik S
Nat Med 2005 Jan 11(1):50-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Patricia Finn
Evaluated 26 Jan 2005

Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs.
Uprichard SL, Boyd B, Althage A, Chisari FV
Proc Natl Acad Sci U S A 2005 Jan 18 102(3):773-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 21 Jan 2005

A pancreatic islet-specific microRNA regulates insulin secretion.
Poy MN, Eliasson L, …, Rorsman P, Stoffel M
Nature 2004 Nov 11 432(7014):226-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Oliver Hobert / Chris Sander / Wolf B. Frommer
Evaluated 12 Nov 2004

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.
Soutschek J, Akinc A, …, Manoharan M, Vornlocher HP
Nature 2004 Nov 11 432(7014):173-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Steven G. Boxer / Charles Coutelle
Evaluated 12 Nov 2004

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.
Mansfield JH, Harfe BD, …, Tabin CJ, McManus MT
Nat Genet 2004 Oct 36(10):1079-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Flint / Fritz Eckstein
Evaluated 9 Nov 2004

Human MicroRNA targets.
John B, Enright AJ, …, Sander C, Marks DS
PLoS Biol 2004 Nov 2(11):e363 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein / Claudia Bagni
Evaluated 20 Oct 2004

Exogenous control of mammalian gene expression through modulation of RNA self-cleavage.
Yen L, Svendsen J, …, D'Amato RJ, Mulligan RC
Nature 2004 Sep 23 431(7007):471-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ian Dunham / Fritz Eckstein
Evaluated 5 Oct 2004

Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA.
Chelliserrykattil J, Ellington AD
Nat Biotechnol 2004 Sep 22(9):1155-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Eaton / Fritz Eckstein / Oliver Weichenrieder
Evaluated 17 Sep 2004

Argonaute2 is the catalytic engine of mammalian RNAi.
Liu J, Carmell MA, …, Joshua-Tor L, Hannon GJ
Science 2004 Sep 3 305(5689):1437-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marjori Matzke / Daniel Gallie / Fritz Eckstein / Miles Wilkinson / Richard Carthew
Evaluated 13 Aug 2004

Cre-lox-regulated conditional RNA interference from transgenes.
Ventura A, Meissner A, …, Jaenisch R, Jacks T
Proc Natl Acad Sci U S A 2004 Jul 13 101(28):10380-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein / Wolfgang Wurst / Scott Lowe
Evaluated 20 Jul 2004

DNA methylation is independent of RNA interference in Neurospora.
Freitag M, Lee DW, …, Aramayo R, Selker EU
Science 2004 Jun 25 304(5679):1939 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 6 Jul 2004

Kinetic analysis of the RNAi enzyme complex.
Haley B, Zamore PD
Nat Struct Mol Biol 2004 Jul 11(7):599-606 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein
Evaluated 8 Jun 2004

Kinetic analysis of ribozyme-substrate complex formation in yeast.
Yadava RS, Mahen EM, Fedor MJ
RNA 2004 May 10(5):863-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 11 May 2004

A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila.
Pham JW, Pellino JL, …, Carthew RW, Sontheimer EJ
Cell 2004 Apr 2 117(1):83-94 [abstract on PubMed] [related articles] [order article]
Selected by | Fritz Eckstein
Evaluated 16 Apr 2004

Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K. Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D. Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
Evaluated 29 Mar 2004

Inducible, reversible, and stable RNA interference in mammalian cells.
Gupta S, Schoer RA, …, Hannon GJ, Mittal V
Proc Natl Acad Sci U S A 2004 Feb 17 101(7):1927-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein / Richard L. Stevens
Evaluated 8 Mar 2004

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells.
Scacheri PC, Rozenblatt-Rosen O, …, Meyerson M, Collins FS
Proc Natl Acad Sci U S A 2004 Feb 17 101(7):1892-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein / Carol Otey
Evaluated 19 Feb 2004

Generating a synthetic genome by whole genome assembly: phiX174 bacteriophage from synthetic oligonucleotides.
Smith HO, Hutchison CA, Pfannkoch C, Venter JC
Proc Natl Acad Sci U S A 2003 Dec 23 100(26):15440-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 4 Feb 2004

Sequence-specific detection of MicroRNAs by signal-amplifying ribozymes.
Hartig JS, Grüne I, Najafi-Shoushtari SH, Famulok M
J Am Chem Soc 2004 Jan 28 126(3):722-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Eric Anslyn
Evaluated 4 Feb 2004

Aptamer redesigned tRNA is nonfunctional and degraded in cells.
Lee D, McClain WH
RNA 2004 Jan 10(1):7-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 6 Jan 2004

Dicer is essential for mouse development.
Bernstein E, Kim SY, …, Anderson KV, Hannon GJ
Nat Genet 2003 Nov 35(3):215-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Carthew / Frank Lyko / Yasushi Okazaki / Fritz Eckstein
Evaluated 18 Dec 2003

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.
Santulli-Marotto S, Nair SK, …, Sullenger B, Gilboa E
Cancer Res 2003 Nov 1 63(21):7483-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 21 Nov 2003

Asymmetry in the assembly of the RNAi enzyme complex.
Schwarz DS, Hutvágner G, …, Aronin N, Zamore PD
Cell 2003 Oct 17 115(2):199-208 [abstract on PubMed] [related articles] [order article]
Selected by | James Carrington / Gregory Hannon / Fritz Eckstein / Daniel Reines
Evaluated 14 Nov 2003

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Hacein-Bey-Abina S, Von Kalle C, …, Fischer A, Cavazzana-Calvo M
Science 2003 Oct 17 302(5644):415-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gerald Spangrude / Fritz Eckstein
Evaluated 5 Nov 2003

Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli.
Massé E, Escorcia FE, Gottesman S
Genes Dev 2003 Oct 1 17(19):2374-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tina Henkin / Fritz Eckstein
Evaluated 27 Oct 2003

siRNA function in RNAi: a chemical modification analysis.
Chiu YL, Rana TM
RNA 2003 Sep 9(9):1034-48 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 26 Sep 2003

Activation of the interferon system by short-interfering RNAs.
Sledz CA, Holko M, …, Silverman RH, Williams BR
Nat Cell Biol 2003 Sep 5(9):834-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Howard / Fritz Eckstein
Evaluated 15 Sep 2003

Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity.
Khvorova A, Lescoute A, Westhof E, Jayasena SD
Nat Struct Biol 2003 Sep 10(9):708-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald Burke / Fritz Eckstein / Barry Stoddard
Evaluated 5 Sep 2003

The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides.
Kretschmer-Kazemi Far R, Sczakiel G
Nucleic Acids Res 2003 Aug 1 31(15):4417-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein
Evaluated 4 Sep 2003