Patricia C. Weber sponsors free access to F1000 for Institute of Research in Physical Chemistry of Cordoba, National University of Córdoba, Argentina. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Patricia set up sponsorship of the Institute of Research in Physical Chemistry of Cordoba with help from José Duca, Class of 1990.

A novel hemoglobin, Bonn, causes falsely decreased oxygen saturation measurements in pulse oximetry. Zur B, Hornung A, …, Ludwig M, Stoffel-Wagner B Clin Chem 2008 Mar 54(3):594-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 23 Jun 2008 Crystal structure of the NS3 protease-helicase from dengue virus. Luo D, Xu T, …, Vasudevan SG, Lescar J J Virol 2008 Jan 82(1):173-83 [abstract on PubMed] [related articles] [FREE full text] Selected by | Richard Kuhn / Patricia C. Weber Evaluated 30 Apr 2008 Prediction of reversibly oxidized protein cysteine thiols using protein structure properties. Sanchez R, Riddle M, Woo J, Momand J Protein Sci 2008 Mar 17(3):473-81 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 19 Mar 2008 Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Rasmussen SG, Choi HJ, …, Weis WI, Kobilka BK Nature 2007 Nov 15 450(7168):383-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Leonardo Pardo / Fred Dyda / Carmen Dessauer / Arthur Christopoulos / Patricia C. Weber / Ian Hall / Marc Caron / Stephan Nussberger Evaluated 3 Dec 2007 High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Cherezov V, Rosenbaum DM, …, Kobilka BK, Stevens RC Science 2007 Nov 23 318(5854):1258-65 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Xiayang Qiu / Mark von Zastrow / Peter Artymiuk / Patricia C. Weber / Ram Samudrala / Petra Fromme / Marc Caron Evaluated 3 Dec 2007 Determination of the sites of tyrosine O-sulfation in peptides and proteins. Yu Y, Hoffhines AJ, Moore KL, Leary JA Nat Methods 2007 Jul 4(7):583-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 16 Aug 2007 A decade of fragment-based drug design: strategic advances and lessons learned. Hajduk PJ, Greer J Nat Rev Drug Discov 2007 Mar 6(3):211-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 9 May 2007 Structural definition of a conserved neutralization epitope on HIV-1 gp120. Zhou T, Xu L, …, Nabel GJ, Kwong PD Nature 2007 Feb 15 445(7129):732-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber / Rino Rappuoli Evaluated 6 Mar 2007 Effects of additives on surfactant phase behavior relevant to bacteriorhodopsin crystallization. Berger BW, Gendron CM, Lenhoff AM, Kaler EW Protein Sci 2006 Dec 15(12):2682-96 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber / Petra Fromme Evaluated 22 Jan 2007 Hydrogen exchange and mass spectrometry: A historical perspective. Englander SW J Am Soc Mass Spectrom 2006 Nov 17(11):1481-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 30 Oct 2006 Structure of the catalytic domain of the hepatitis C virus NS2-3 protease. Lorenz IC, Marcotrigiano J, Dentzer TG, Rice CM Nature 2006 Aug 17 442(7104):831-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Daniel Lamarre / Robert Booth / Peter Artymiuk / Robert Lanford / Patricia C. Weber / Liang Tong Evaluated 14 Aug 2006 Structure and dynamics of dark-state bovine rhodopsin revealed by chemical cross-linking and high-resolution mass spectrometry. Jacobsen RB, Sale KL, …, Young MM, Schoeniger JS Protein Sci 2006 Jun 15(6):1303-17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 13 Jun 2006 Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein. Ignatova Z, Gierasch LM J Biol Chem 2006 May 5 281(18):12959-67 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 9 May 2006 Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome. Rodríguez-Ortega MJ, Norais N, …, Telford JL, Grandi G Nat Biotechnol 2006 Feb 24(2):191-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber / Victor Nizet Evaluated 4 Apr 2006 RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Dumont S, Cheng W, …, Pyle AM, Bustamante C Nature 2006 Jan 5 439(7072):105-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 20 Jan 2006 Structure of a V3-containing HIV-1 gp120 core. Huang CC, Tang M, …, Wyatt R, Kwong PD Science 2005 Nov 11 310(5750):1025-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 6 Dec 2005 Structural basis of energy transduction in the transport cycle of MsbA. Dong J, Yang G, McHaourab HS Science 2005 May 13 308(5724):1023-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | D. Peter Tieleman / Christoph Benning / Patricia C. Weber Evaluated 16 Jun 2005 Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Tellinghuisen TL, Marcotrigiano J, Rice CM Nature 2005 May 19 435(7040):374-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 26 May 2005 Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. Biswal BK, Cherney MM, …, Bedard J, James MN J Biol Chem 2005 May 6 280(18):18202-10 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 20 May 2005 Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Ortlund EA, Lee Y, …, Moore DD, Redinbo MR Nat Struct Mol Biol 2005 Apr 12(4):357-63 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 25 Apr 2005 Protein aggregation determinants from a simplified model: cooperative folders resist aggregation. Clark LA Protein Sci 2005 Mar 14(3):653-62 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 7 Mar 2005 Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor. Kim J, Lee J, …, Logan TM, Blaber M Protein Sci 2005 Feb 14(2):351-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 15 Feb 2005 Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Ohren JF, Chen H, …, Tecle H, Hasemann CA Nat Struct Mol Biol 2004 Dec 11(12):1192-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 20 Dec 2004 Crystal structure of human coactosin-like protein at 1.9 A resolution. Li X, Liu X, …, Liu Y, Rao Z Protein Sci 2004 Nov 13(11):2845-51 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 9 Nov 2004 Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Williams PA, Cosme J, …, Tickle IJ, Jhoti H Science 2004 Jul 30 305(5684):683-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber / Michael Gelb Evaluated 19 Aug 2004 The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. Yano JK, Wester MR, …, Stout CD, Johnson EF J Biol Chem 2004 Sep 10 279(37):38091-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 19 Aug 2004 Analysis of the "thermodynamic information content" of a Homo sapiens structural database reveals hierarchical thermodynamic organization. Larson SA, Hilser VJ Protein Sci 2004 Jul 13(7):1787-801 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 5 Jul 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Paez JG, Jänne PA, …, Johnson BE, Meyerson M Science 2004 Jun 4 304(5676):1497-500 [abstract on PubMed] [related articles] [FREE full text] Selected by | William Kaelin / Patricia C. Weber / Joachim Herz / Charles Streuli / Alfred Wittinghofer / Charles Brenner Evaluated 14 May 2004 Structure of fosfomycin resistance protein FosA from transposon Tn2921. Pakhomova S, Rife CL, Armstrong RN, Newcomer ME Protein Sci 2004 May 13(5):1260-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 30 Apr 2004 An improved crystal form of Plasmodium falciparum peptide deformylase. Robien MA, Nguyen KT, …, Pei D, Hol WG Protein Sci 2004 Apr 13(4):1155-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 8 Apr 2004 In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms. Lin C, Lin K, …, Gates CA, Kwong AD J Biol Chem 2004 Apr 23 279(17):17508-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 3 Mar 2004 Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Pantazatos D, Kim JS, …, Lesley SA, Woods VL Proc Natl Acad Sci U S A 2004 Jan 20 101(3):751-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber / Celerino Abad-Zapatero / Song Tan / David Waugh Evaluated 23 Jan 2004 Crystal structure of an invertebrate caspase. Forsyth CM, Lemongello D, …, Friesen PD, Fisher AJ J Biol Chem 2004 Feb 20 279(8):7001-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 18 Dec 2003 X-ray crystal structure of IRF-3 and its functional implications. Takahasi K, Suzuki NN, …, Fujita T, Inagaki F Nat Struct Biol 2003 Nov 10(11):922-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 5 Nov 2003 Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Qin BY, Liu C, …, Derynck R, Lin K Nat Struct Biol 2003 Nov 10(11):913-21 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 5 Nov 2003 Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Friedrich R, Panizzi P, …, Bode W, Bock PE Nature 2003 Oct 2 425(6957):535-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 28 Oct 2003 The crystal structure of Escherichia coli heat shock protein YedU reveals three potential catalytic active sites. Zhao Y, Liu D, …, White MA, Fox RO Protein Sci 2003 Oct 12(10):2303-11 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 29 Sep 2003 Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals. Kantardjieff KA, Rupp B Protein Sci 2003 Sep 12(9):1865-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 3 Sep 2003 Crystal structure of human cytochrome P450 2C9 with bound warfarin. Williams PA, Cosme J, …, Matak Vinkovi¿ D, Jhoti H Nature 2003 Jul 24 424(6947):464-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber / Jane Endicott Evaluated 4 Aug 2003 Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Sabini E, Ort S, …, Konrad M, Lavie A Nat Struct Biol 2003 Jul 10(7):513-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 17 Jul 2003 The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Henrich S, Cameron A, …, Bode W, Than ME Nat Struct Biol 2003 Jul 10(7):520-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber / Barry Stoddard Evaluated 23 Jun 2003 Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Lodowski DT, Pitcher JA, …, Lefkowitz RJ, Tesmer JJ Science 2003 May 23 300(5623):1256-62 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber / Tetsuji Okada / Stephen Sprang / David Cowburn Evaluated 5 Jun 2003 Insights into antifolate resistance from malarial DHFR-TS structures. Yuvaniyama J, Chitnumsub P, …, Walkinshaw MD, Yuthavong Y Nat Struct Biol 2003 May 10(5):357-65 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Carol Sibley / Vivian Cody / Karen Anderson / Patricia C. Weber Evaluated 22 May 2003 A novel protein-mineral interface. Alexeev D, Zhu H, …, Campopiano DJ, Sadler PJ Nat Struct Biol 2003 Apr 10(4):297-302 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 23 Apr 2003 Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. O'Farrell D, Trowbridge R, Rowlands D, Jäger J J Mol Biol 2003 Feb 28 326(4):1025-35 [abstract on PubMed] [related articles] [order article] Selected by | Patricia C. Weber Evaluated 21 Mar 2003 Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. Wang M, Ng KK, …, Bethell RC, James MN J Biol Chem 2003 Mar 14 278(11):9489-95 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 21 Mar 2003 The unusual catalytic triad of poliovirus protease 3C. Sárkány Z, Polgár L Biochemistry 2003 Jan 21 42(2):516-22 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 12 Feb 2003 Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain. Anand K, Palm GJ, …, Ziebuhr J, Hilgenfeld R EMBO J 2002 Jul 1 21(13):3213-24 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 10 Jan 2003 Extension of a local backbone description using a structural alphabet: a new approach to the sequence-structure relationship. de Brevern AG, Valadié H, Hazout S, Etchebest C Protein Sci 2002 Dec 11(12):2871-86 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 4 Dec 2002 Construction of a fluorescent biosensor family. de Lorimier RM, Smith JJ, …, Loew L, Hellinga HW Protein Sci 2002 Nov 11(11):2655-75 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber / Andrew Ellington Evaluated 6 Nov 2002 The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region. Marquardt U, Zettl F, …, Bode W, Sommerhoff C J Mol Biol 2002 Aug 16 321(3):491-502 [abstract on PubMed] [related articles] [order article] Selected by | Patricia C. Weber / Richard L. Stevens Evaluated 9 Oct 2002 Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-A resolution: a large conformational change in ADP-dependent glucokinase. Tsuge H, Sakuraba H, …, Katunuma N, Ohshima T Protein Sci 2002 Oct 11(10):2456-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 9 Oct 2002 Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Hunt JF, Weinkauf S, …, Oliver DB, Deisenhofer J Science 2002 Sep 20 297(5589):2018-26 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber / Wil Konings Evaluated 3 Oct 2002 The structural basis for specificity in human ABO(H) blood group biosynthesis. Patenaude SI, Seto NO, …, Palcic MM, Evans SV Nat Struct Biol 2002 Sep 9(9):685-90 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 10 Sep 2002 A novel fucose recognition fold involved in innate immunity. Bianchet MA, Odom EW, Vasta GR, Amzel LM Nat Struct Biol 2002 Aug 9(8):628-34 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 15 Aug 2002 Overcoming drug resistance in HIV-1 chemotherapy: the binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease. Ohtaka H, Velázquez-Campoy A, Xie D, Freire E Protein Sci 2002 Aug 11(8):1908-16 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 6 Aug 2002 Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex. Murakami KS, Masuda S, …, Muzzin O, Darst SA Science 2002 May 17 296(5571):1285-90 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Dutnall / Patricia C. Weber Evaluated 2 Jul 2002 Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Vassylyev DG, Sekine S, …, Borukhov S, Yokoyama S Nature 2002 Jun 13 417(6890):712-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 2 Jul 2002 Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Murakami KS, Masuda S, Darst SA Science 2002 May 17 296(5571):1280-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 1 Jul 2002 Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects. Krantz BA, Srivastava AK, …, Sauer RT, Sosnick TR Nat Struct Biol 2002 Jun 9(6):458-63 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Patricia C. Weber Evaluated 10 Jun 2002 Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Zhang K, Rathod PK Science 2002 Apr 19 296(5567):545-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | David Matthews / Ruma Banerjee / Patricia C. Weber / Karen Anderson Evaluated 8 May 2002 Breaking the singleton of germination protease. Pei J, Grishin NV Protein Sci 2002 Mar 11(3):691-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 27 Mar 2002 Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)(10)](3). Berisio R, Vitagliano L, Mazzarella L, Zagari A Protein Sci 2002 Feb 11(2):262-70 [abstract on PubMed] [related articles] [FREE full text] Selected by | Patricia C. Weber Evaluated 14 Mar 2002

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