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Martin A. Schwartz
Department of Microbiology, University of Virginia, Charlottesville, United States of America

Faculty Member: CELL BIOLOGY > Cell adhesion [ since 4 July 2001 ]
[ Homepage ] [ Evaluations ]
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http://www.healthsystem.virginia.edu/internet/microbiology/faculty/facultyalphaall.cfm?uva_id=mas5bm&

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Evaluations

Kindlin-2 (Mig-2): a co-activator of beta3 integrins.
Ma YQ, Qin J, Wu C, Plow EF
J Cell Biol 2008 May 5 181(3):439-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Mark Ginsberg / Xiaoping Du / Martin Humphries
Evaluated 9 May 2008

VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
Rudini N, Felici A, …, ten Dijke P, Dejana E
EMBO J 2008 Apr 9 27(7):993-1004 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Chen / Kathleen J. Green / Martin A. Schwartz
Evaluated 21 Apr 2008

Crag regulates epithelial architecture and polarized deposition of basement membrane proteins in Drosophila.
Denef N, Chen Y, …, Barcelo G, Schüpbach T
Dev Cell 2008 Mar 14(3):354-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / David Sherwood / David Stephens / Ross Cagan
Evaluated 28 Mar 2008

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.
Gavard J, Patel V, Gutkind JS
Dev Cell 2008 Jan 14(1):25-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Kathleen J. Green / Yoshimi Takai
Evaluated 7 Feb 2008

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Gaggioli C, Hooper S, …, Harrington K, Sahai E
Nat Cell Biol 2007 Dec 9(12):1392-400 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Filippo Giancotti / Carol Otey / Frank de Gruijl / C. Michael DiPersio / Anna Huttenlocher / Kathleen J. Green
Evaluated 17 Dec 2007

CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling.
Féral CC, Zijlstra A, …, Slepak M, Ginsberg MH
J Cell Biol 2007 Aug 13 178(4):701-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 28 Aug 2007

Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.
Zhu J, Carman CV, …, Springer TA, Luo BH
Blood 2007 Oct 1 110(7):2475-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 31 Jul 2007

Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis.
Mahabeleshwar GH, Feng W, …, Plow EF, Byzova TV
Circ Res 2007 Sep 14 101(6):570-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 31 Jul 2007

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.
Kitzing TM, Sahadevan AS, …, Grosshans J, Grosse R
Genes Dev 2007 Jun 15 21(12):1478-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 2 Jul 2007

The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Sablina AA, Chen W, …, DeCaprio JA, Hahn WC
Cell 2007 Jun 1 129(5):969-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 12 Jun 2007

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.
Curto M, Cole BK, …, Liu CH, McClatchey AI
J Cell Biol 2007 Jun 4 177(5):893-903 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 12 Jun 2007

Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains.
Co C, Wong DT, …, Chang V, Taunton J
Cell 2007 Mar 9 128(5):901-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Pekka Lappalainen / Matthew Welch / Marie-France Carlier / Martin A. Schwartz
Evaluated 4 Apr 2007

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.
Santos SD, Verveer PJ, Bastiaens PI
Nat Cell Biol 2007 Mar 9(3):324-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Andrius Kazlauskas / Alfred Wittinghofer
Evaluated 8 Mar 2007


Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors.
Kawashima T, Bao YC, …, Williams DA, Kitamura T
J Cell Biol 2006 Dec 18 175(6):937-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Ed Manser / Brent Cochran
Evaluated 3 Jan 2007

Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration.
Osmani N, Vitale N, Borg JP, Etienne-Manneville S
Curr Biol 2006 Dec 19 16(24):2395-405 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 3 Jan 2007

Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly.
Sturge J, Wienke D, Isacke CM
J Cell Biol 2006 Oct 23 175(2):337-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Viki Allan
Evaluated 2 Nov 2006

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Chien Y, Kim S, …, Zhao Y, White MA
Cell 2006 Oct 6 127(1):157-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / John Kyriakis / Caetano Reis e Sousa / David Wallach / Ruth Collins
Evaluated 11 Oct 2006

Cellular asymmetry and individuality in directional sensing.
Samadani A, Mettetal J, van Oudenaarden A
Proc Natl Acad Sci U S A 2006 Aug 1 103(31):11549-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 18 Aug 2006

Endothelial tubes assemble from intracellular vacuoles in vivo.
Kamei M, Saunders WB, …, Davis GE, Weinstein BM
Nature 2006 Jul 27 442(7101):453-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Manfred Schliwa / Marta Llimargas / Derek Stemple
Evaluated 9 Aug 2006

Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading.
Yoo Y, Wu X, …, Li R, Guan JL
J Biol Chem 2006 Jun 2 281(22):15352-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 5 May 2006

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
Guthridge MA, Powell JA, …, Begley CG, Lopez AF
EMBO J 2006 Feb 8 25(3):479-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 24 Feb 2006

Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
Kobayashi T, Hino S, …, Yasui W, Kikuchi A
Mol Cell Biol 2006 Feb 26(3):898-911 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 27 Jan 2006

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.
Czuchra A, Wu X, …, Rottner K, Brakebusch C
Mol Biol Cell 2005 Oct 16(10):4473-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Mark Ginsberg / Anne Ridley / Martin A. Schwartz
Evaluated 6 Jan 2006

Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration.
Li J, Ballif BA, …, Gygi SP, Hsu VW
Dev Cell 2005 Nov 9(5):663-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 19 Dec 2005

Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control.
Gan B, Melkoumian ZK, …, Guan KL, Guan JL
J Cell Biol 2005 Aug 1 170(3):379-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 15 Aug 2005

PIP2 signaling in lipid domains: a critical re-evaluation.
van Rheenen J, Achame EM, …, Calafat J, Jalink K
EMBO J 2005 May 4 24(9):1664-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Leah Keshet
Evaluated 22 Jul 2005

Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation.
van Buul JD, Anthony EC, …, Burridge K, Hordijk PL
J Biol Chem 2005 Jun 3 280(22):21129-36 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 5 Apr 2005

Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.
Chen X, Macara IG
Nat Cell Biol 2005 Mar 7(3):262-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Alan Fanning / Carien Niessen
Evaluated 11 Mar 2005

PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Nishimura T, Yamaguchi T, …, Hoshino M, Kaibuchi K
Nat Cell Biol 2005 Mar 7(3):270-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Chernoff / Martin A. Schwartz
Evaluated 11 Mar 2005

Conversion of mechanical force into biochemical signaling.
Han B, Bai XH, …, Post M, Liu M
J Biol Chem 2004 Dec 24 279(52):54793-801 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 4 Jan 2005

Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization.
Paik JH, Skoura A, …, Proia RL, Hla T
Genes Dev 2004 Oct 1 18(19):2392-403 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 29 Nov 2004

Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis.
Ishibe S, Joly D, Liu ZX, Cantley LG
Mol Cell 2004 Oct 22 16(2):257-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Charles Streuli
Evaluated 17 Nov 2004

Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.
DerMardirossian C, Schnelzer A, Bokoch GM
Mol Cell 2004 Jul 2 15(1):117-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ron Prywes / Martin A. Schwartz / Jacqueline Cherfils / Orion Weiner
Evaluated 14 Jul 2004

ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts.
Komatsu S, Ikebe M
J Cell Biol 2004 Apr 26 165(2):243-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 10 May 2004

Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins.
Roberts MS, Woods AJ, …, Van Der Sluijs P, Norman JC
Mol Cell Biol 2004 Feb 24(4):1505-15 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 16 Feb 2004

Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction.
Cooper LA, Shen TL, Guan JL
Mol Cell Biol 2003 Nov 23(22):8030-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Kristiina Vuori
Evaluated 10 Nov 2003

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain.
Arias-Salgado EG, Lizano S, …, Ginsberg MH, Shattil SJ
Proc Natl Acad Sci U S A 2003 Nov 11 100(23):13298-302 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Cowburn / Martin A. Schwartz / Kenneth Yamada
Evaluated 10 Nov 2003

Molecular pathway for cancer metastasis to bone.
De S, Chen J, …, Sage EH, Byzova TV
J Biol Chem 2003 Oct 3 278(40):39044-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 2 Sep 2003

Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts.
Funakoshi-Tago M, Sonoda Y, …, Tominaga S, Kasahara T
J Biol Chem 2003 Aug 1 278(31):29359-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 2 Sep 2003

Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal.
Shibanuma M, Kim-Kaneyama JR, …, Mashimo J, Nose K
Mol Biol Cell 2003 Mar 14(3):1158-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 12 May 2003

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.
Pankov R, Cukierman E, …, Poulin B, Yamada KM
J Biol Chem 2003 May 16 278(20):18671-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 24 Mar 2003

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Calderwood DA, Fujioka Y, …, Liddington RC, Ginsberg MH
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2272-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Timothy Springer / Alan Rick Horwitz / Martin A. Schwartz / Martin Humphries
Evaluated 14 Mar 2003

Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion.
DeMali KA, Barlow CA, Burridge K
J Cell Biol 2002 Dec 9 159(5):881-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Kenneth Yamada
Evaluated 19 Dec 2002

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.
Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L
Cancer Cell 2002 Jun 1(5):445-57 [abstract on PubMed] [related articles] [order article]
Selected by | M. Sharon Stack / Martin A. Schwartz
Evaluated 16 Aug 2002

Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.
Moro L, Dolce L, …, Tarone G, Defilippi P
J Biol Chem 2002 Mar 15 277(11):9405-14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Richard Assoian
Evaluated 21 Mar 2002

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
Trusolino L, Bertotti A, Comoglio PM
Cell 2001 Nov 30 107(5):643-54 [abstract on PubMed] [related articles] [order article]
Selected by | Michael Schaller / Ruediger Klein / Kristiina Vuori / Martin A. Schwartz
Evaluated 2 Jan 2002

Cell motility: ARNOand ARF6 at the cutting edge.
Turner CE, Brown MC
Curr Biol 2001 Oct 30 11(21):R875-7 [abstract on PubMed] [related articles] [order article]
Selected by | Martin A. Schwartz
Evaluated 21 Dec 2001

Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains.
Woodside DG, Obergfell A, …, Shattil SJ, Ginsberg MH
Curr Biol 2001 Nov 13 11(22):1799-804 [abstract on PubMed] [related articles] [order article]
Selected by | Martin A. Schwartz
Evaluated 5 Dec 2001

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Snapper SB, Takeshima F, …, Hartwig JH, Alt FW
Nat Cell Biol 2001 Oct 3(10):897-904 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz
Evaluated 25 Oct 2001

Cadherin engagement regulates Rho family GTPases.
Noren NK, Niessen CM, Gumbiner BM, Burridge K
J Biol Chem 2001 Sep 7 276(36):33305-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / James Anderson / Ed Manser
Evaluated 9 Oct 2001

The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes.
Yang W, Lin Q, …, Guan JL, Cerione RA
J Biol Chem 2001 Nov 23 276(47):43987-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz
Evaluated 2 Oct 2001

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