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Stanley Nattel
University of Montreal, Canada

Faculty Member: PHARMACOLOGY & DRUG DISCOVERY > Cardiovascular pharmacology [ since 2 August 2006 ]
[ Biography ] [ Evaluations ]
Biography

Dr. Nattel obtained an MDCM from McGill University (Montreal) in 1974 and then trained in Internal Medicine and Clinical Pharmacology (McGill University), Cardiology (University of Indiana) and Physiology (University of Pennsylvania). He has been on faculty at McGill University since 1981 and University of Montreal since 1987, where he is presently Professor of Medicine and Paul-David Chair in Cardiovascular Electrophysiology. Dr Nattel has been a staff cardiologist at the Montreal Heart Institute since 1987, where he served as Scientific Director of the Research Center between 1990 and 2004. His research interests are primarily in clinically-relevant cardiac electrophysiology, particularly as pertains to the development of novel mechanistically-based therapeutic approaches to cardiac arrhythmias. His most important contributions have been in the understanding of the basic physiology, pharmacology, biophysics and molecular biology of cardiac ion channels and in the appreciation of the pathophysiology of cardiac arrhythmias at the molecular and systems biology levels. His laboratory has been at the forefront of the development of many new antiarrhythmic drugs and novel drug targets and has been involved in extensive partnerships with the innovative pharmaceutical industry sector.

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Evaluations

Atrial and ventricular fibrosis induced by atrial fibrillation: Evidence to support early rhythm control.
Avitall B, Bi J, Mykytsey A, Chicos A
Heart Rhythm 2008 Jun 5(6):839-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 23 Jun 2008

Novel transient outward and ultra-rapid delayed rectifier current antagonist, AVE0118, protects against ventricular fibrillation induced by myocardial ischemia.
Billman GE, Kukielka M
J Cardiovasc Pharmacol 2008 Apr 51(4):352-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 23 Jun 2008

Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5-antisense inhibition.
Maltsev VA, Kyle JJ, Mishra S, Undrovinas AA
Am J Physiol Heart Circ Physiol 2008 Jun 13 [abstract on PubMed] [related articles] [full text]
Selected by | Stanley Nattel
Evaluated 23 Jun 2008

Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy.
Marionneau C, Brunet S, …, Demolombe S, Nerbonne JM
Circ Res 2008 Jun 6 102(11):1406-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 23 Jun 2008

A mutation in telethonin alters Nav1.5 function.
Mazzone A, Strege PR, …, Ackerman MJ, Farrugia G
J Biol Chem 2008 Apr 11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel
Evaluated 27 May 2008

Downregulation of MIRNA-1/MIRNA-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart.
Luo X, Lin H, …, Yang B, Wang Z
J Biol Chem 2008 May 5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel
Evaluated 15 May 2008

Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.
Yamamoto T, Yano M, …, Ikemoto N, Matsuzaki M
Circulation 2008 Feb 12 117(6):762-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Graham Lamb / Stanley Nattel
Evaluated 31 Mar 2008


Cell therapy for modification of the myocardial electrophysiological substrate.
Yankelson L, Feld Y, …, Marom S, Gepstein L
Circulation 2008 Feb 12 117(6):720-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 31 Mar 2008

Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression.
Goette A, Bukowska A, …, Klein HU, Röcken C
Circulation 2008 Feb 12 117(6):732-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 15 Feb 2008

Combined metabolomic and proteomic analysis of human atrial fibrillation.
Mayr M, Yusuf S, …, Xu Q, Camm AJ
J Am Coll Cardiol 2008 Feb 5 51(5):585-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 15 Feb 2008

The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG).
Sinner MF, Pfeufer A, …, Meitinger T, Kääb S
Eur Heart J 2008 Jan 25 [abstract on PubMed] [related articles] [full text]
Selected by | Stanley Nattel
Evaluated 15 Feb 2008

The KCNQ1 (Kv7.1) C-terminus, a multi-tieredscaffold for subunit assembly and protein interaction.
Wiener R, Haitin Y, …, Attali B, Hirsch JA
J Biol Chem 2007 Dec 29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel
Evaluated 10 Jan 2008

Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study.
Newton-Cheh C, Guo CY, …, Hirschhorn JN, O'donnell CJ
Circulation 2007 Sep 4 116(10):1128-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 20 Nov 2007

Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine.
Burashnikov A, Di Diego JM, …, Belardinelli L, Antzelevitch C
Circulation 2007 Sep 25 116(13):1449-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 20 Nov 2007

Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure.
Tanaka K, Zlochiver S, …, Berenfeld O, Kalifa J
Circ Res 2007 Oct 12 101(8):839-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 6 Sep 2007

Role of Rac1 GTPase activation in atrial fibrillation.
Adam O, Frost G, …, Böhm M, Laufs U
J Am Coll Cardiol 2007 Jul 24 50(4):359-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 9 Aug 2007

Atrial glutathione content, calcium current, and contractility.
Carnes CA, Janssen PM, …, Hamlin RL, Van Wagoner DR
J Biol Chem 2007 Sep 21 282(38):28063-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 9 Aug 2007

Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites.
Ozgen N, Dun W, …, Boyden PA, Rosen MR
Cardiovasc Res 2007 Sep 1 75(4):758-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 23 Jul 2007

Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node.
Ju YK, Chu Y, …, Cannell MB, Allen DG
Circ Res 2007 Jun 8 100(11):1605-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dirk van Helden / Stanley Nattel
Evaluated 23 Jul 2007

Endoscopic fluorescence mapping of the left atrium: a novel experimental approach for high resolution endocardial mapping in the intact heart.
Kalifa J, Klos M, …, Jalife J, Berenfeld O
Heart Rhythm 2007 Jul 4(7):916-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel
Evaluated 23 Jul 2007

Co-chaperone FKBP38 promotes HERG trafficking.
Walker VE, Atanasiu R, Lam H, Shrier A
J Biol Chem 2007 Aug 10 282(32):23509-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 18 Jul 2007

SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.
Medeiros-Domingo A, Kaku T, …, Makielski JC, Ackerman MJ
Circulation 2007 Jul 10 116(2):134-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 18 Jul 2007

MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts.
Xiao J, Luo X, …, Yang B, Wang Z
J Biol Chem 2007 Apr 27 282(17):12363-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 3 Apr 2007

Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?
Otway R, Vandenberg JI, …, Thorburn C, Fatkin D
J Am Coll Cardiol 2007 Feb 6 49(5):578-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 12 Feb 2007

Integrin activation in the heart: a link between electrical and contractile dysfunction?
Valencik ML, Zhang D, …, McDonald JA, Litwin SE
Circ Res 2006 Dec 8 99(12):1403-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 23 Jan 2007

Molecular ablation of ventricular tachycardia after myocardial infarction.
Sasano T, McDonald AD, Kikuchi K, Donahue JK
Nat Med 2006 Nov 12(11):1256-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel / Charles Coutelle
Evaluated 5 Jan 2007

Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation.
Kistler PM, Sanders P, …, Edwards GA, Kalman JM
Eur Heart J 2006 Dec 27(24):3045-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel
Evaluated 22 Nov 2006

Pirfenidone prevents the development of a vulnerable substrate for atrial fibrillation in a canine model of heart failure.
Lee KW, Everett TH, …, Ding C, Olgin JE
Circulation 2006 Oct 17 114(16):1703-12 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stanley Nattel
Evaluated 27 Oct 2006

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