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Daniel Reines
Department of Biochemistry, Emory University School of Medicine, Atlanta, United States of America

Faculty Member: Cell Biology > Control of Gene Expression [ since 25 July 2001 ]
[ Sponsorship ] [ Evaluations ]
Sponsorship

Daniel Reines sponsors free access to F1000 for International Centre for Genetic Engineering, New Delhi, India. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

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Evaluations

Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes.
Goler-Baron V, Selitrennik M, …, Lotan R, Choder M
Genes Dev 2008 Aug 1 22(15):2022-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 14 Aug 2008

Sir2 silences gene transcription by targeting the transition between RNA polymerase II initiation and elongation.
Gao L, Gross DS
Mol Cell Biol 2008 Jun 28(12):3979-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 7 Jul 2008

Functions of Saccharomyces cerevisiae TFIIF during transcription start site utilization.
Khaperskyy DA, Ammerman ML, Majovski RC, Ponticelli AS
Mol Cell Biol 2008 Jun 28(11):3757-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 20 May 2008

Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeast.
El Hage A, Koper M, Kufel J, Tollervey D
Genes Dev 2008 Apr 15 22(8):1069-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 23 Apr 2008

Single-molecule tracking of mRNA exiting from RNA polymerase II.
Andrecka J, Lewis R, …, Cramer P, Michaelis J
Proc Natl Acad Sci U S A 2008 Jan 8 105(1):135-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 17 Mar 2008

Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression.
Egloff S, O'Reilly D, …, Eick D, Murphy S
Science 2007 Dec 14 318(5857):1777-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Pamela Geyer / Daniel Reines
Evaluated 14 Feb 2008

Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome.
Beilharz TH, Preiss T
RNA 2007 Jul 13(7):982-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jurg Bahler / Daniel Reines
Evaluated 20 Dec 2007

A transcription-independent role for TFIIB in gene looping.
Singh BN, Hampsey M
Mol Cell 2007 Sep 7 27(5):806-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Meisterernst / Daniel Reines
Evaluated 21 Nov 2007

In vivo dynamics of RNA polymerase II transcription.
Darzacq X, Shav-Tal Y, …, Phair RD, Singer RH
Nat Struct Mol Biol 2007 Sep 14(9):796-806 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dinah Singer / Thomas Kodadek / Daniel Reines / Sui Huang
Evaluated 19 Oct 2007

Effects of aneuploidy on cellular physiology and cell division in haploid yeast.
Torres EM, Sokolsky T, …, Dunham MJ, Amon A
Science 2007 Aug 17 317(5840):916-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 17 Sep 2007

The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex.
Chen HT, Warfield L, Hahn S
Nat Struct Mol Biol 2007 Aug 14(8):696-703 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 28 Aug 2007

Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae.
Dobi KC, Winston F
Mol Cell Biol 2007 Aug 27(15):5575-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jim Maher / Daniel Reines
Evaluated 27 Jul 2007

The RNA polymerase II CTD kinase Ctk1 functions in translation elongation.
Röther S, Strässer K
Genes Dev 2007 Jun 1 21(11):1409-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Francesc Posas
Evaluated 18 Jun 2007

Growth control of the eukaryote cell: a systems biology study in yeast.
Castrillo JI, Zeef LA, …, Kell DB, Oliver SG
J Biol 2007 6(2):4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines / Stanley Brul / Peter Mayinger
Evaluated 21 May 2007

Transcription elongation by RNA polymerase I is linked to efficient rRNA processing and ribosome assembly.
Schneider DA, Michel A, …, Beyer AL, Nomura M
Mol Cell 2007 Apr 27 26(2):217-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 30 Apr 2007

Reversal of neurological defects in a mouse model of Rett syndrome.
Guy J, Gan J, …, Cobb S, Bird A
Science 2007 Feb 23 315(5815):1143-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Victor Reus / Jane Hewitt / Daniel Reines
Evaluated 20 Mar 2007


A novel plasmid-based microarray screen identifies suppressors of rrp6Delta in Saccharomyces cerevisiae.
Abruzzi K, Denome S, …, Jensen TH, Rosbash M
Mol Cell Biol 2007 Feb 27(3):1044-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 19 Feb 2007

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.
Thompson DM, Parker R
Mol Cell Biol 2007 Jan 27(1):92-101 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 5 Jan 2007

Genes with internal repeats require the THO complex for transcription.
Voynov V, Verstrepen KJ, …, Buratowski S, Fink GR
Proc Natl Acad Sci U S A 103(39):14423-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 28 Nov 2006

Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis.
Esberg A, Huang B, Johansson MJ, Byström AS
Mol Cell 2006 Oct 6 24(1):139-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ian Willis / Daniel Reines
Evaluated 7 Nov 2006

Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3.
Arigo JT, Eyler DE, Carroll KL, Corden JL
Mol Cell 2006 Sep 15 23(6):841-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Bernhard Dichtl
Evaluated 5 Oct 2006

In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants.
Lacadie SA, Tardiff DF, Kadener S, Rosbash M
Genes Dev 2006 Aug 1 20(15):2055-66 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 14 Aug 2006

Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.
Zofall M, Grewal SI
Mol Cell 2006 Jun 9 22(5):681-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marjori Matzke / Francis Stewart / Daniel Reines
Evaluated 7 Jul 2006

cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II.
Steinmetz EJ, Ng SB, Cloute JP, Brow DA
Mol Cell Biol 2006 Apr 26(7):2688-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bernhard Dichtl / Daniel Reines
Evaluated 15 Jun 2006

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
Yamane K, Toumazou C, …, Wong J, Zhang Y
Cell 2006 May 5 125(3):483-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 11 May 2006

Transcription elongation factor S-II is required for definitive hematopoiesis.
Ito T, Arimitsu N, …, Miyajima A, Sekimizu K
Mol Cell Biol 2006 Apr 26(8):3194-203 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 12 Apr 2006

Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions.
Adkins MW, Tyler JK
Mol Cell 2006 Feb 3 21(3):405-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Tony Weil / Kenneth Zaret / Richard Maraia
Evaluated 21 Feb 2006

Ribozyme cleavage reveals connections between mRNA release from the site of transcription and pre-mRNA processing.
Bird G, Fong N, …, Farabaugh S, Bentley DL
Mol Cell 2005 Dec 9 20(5):747-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bernhard Dichtl / Daniel Reines
Evaluated 20 Jan 2006

Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae.
Martens JA, Wu PY, Winston F
Genes Dev 2005 Nov 15 19(22):2695-704 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines / Thomas Kodadek
Evaluated 9 Dec 2005

A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.
Penheiter KL, Washburn TM, …, Hoffman MG, Jaehning JA
Mol Cell 2005 Oct 28 20(2):213-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Benoit Coulombe
Evaluated 9 Nov 2005

The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation.
Kaneko S, Manley JL
Mol Cell 2005 Oct 7 20(1):91-103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 12 Oct 2005

Histones are required for transcription of yeast rRNA genes by RNA polymerase I.
Tongaonkar P, French SL, …, Beyer AL, Nomura M
Proc Natl Acad Sci U S A 2005 Jul 19 102(29):10129-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 27 Jul 2005

Highly efficient endogenous human gene correction using designed zinc-finger nucleases.
Urnov FD, Miller JC, …, Gregory PD, Holmes MC
Nature 2005 Jun 2 435(7042):646-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard / John Cambier / Makoto Komiyama / Daniel Reines / Charles Coutelle
Evaluated 13 Jul 2005

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase.
Wyers F, Rougemaille M, …, Libri D, Jacquier A
Cell 2005 Jun 3 121(5):725-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Christian Velot / Jurg Bahler
Evaluated 8 Jun 2005

The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
Yart A, Gstaiger M, …, Hess D, Krek W
Mol Cell Biol 2005 Jun 25(12):5052-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 1 Jun 2005

Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation.
Rahl PB, Chen CZ, Collins RN
Mol Cell 2005 Mar 18 17(6):841-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Heike Folsch
Evaluated 29 Mar 2005

An early step in wobble uridine tRNA modification requires the Elongator complex.
Huang B, Johansson MJ, Byström AS
RNA 2005 Apr 11(4):424-36 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 21 Mar 2005

Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation.
Onodera Y, Haag JR, …, Pontes O, Pikaard CS
Cell 2005 Mar 11 120(5):613-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / Frank Lyko / Sui Huang / Lucio Comai / Vivian Irish / Motoaki Seki
Evaluated 18 Mar 2005

Neural progenitor cells from an adult patient with fragile X syndrome.
Schwartz PH, Tassone F, …, Hagerman RJ, Hagerman PJ
BMC Med Genet 2005 Jan 14 6:2 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 22 Feb 2005

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Shi Y, Lan F, …, Casero RA, Shi Y
Cell 2004 Dec 29 119(7):941-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Henikoff / Thomas Jenuwein / Chris Sander / Winship Herr / Dinah Singer / Robert Dutnall / Eric Selker / Frank Lyko / Daniel Reines / Benoit Coulombe / Robin Allshire
Evaluated 17 Jan 2005

The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.
Kim M, Krogan NJ, …, Greenblatt JF, Buratowski S
Nature 2004 Nov 25 432(7016):517-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arlen Johnson / Daniel Reines / Francesc Posas
Evaluated 4 Jan 2005

Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
Westover KD, Bushnell DA, Kornberg RD
Cell 2004 Nov 12 119(4):481-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Dutnall / Daniel Reines / Ronald Conaway / Benoit Coulombe
Evaluated 29 Nov 2004

Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells.
Lorincz MC, Dickerson DR, Schmitt M, Groudine M
Nat Struct Mol Biol 2004 Nov 11(11):1068-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 9 Nov 2004

Modulation of transcription affects mRNP quality.
Jensen TH, Boulay J, …, Weyler M, Libri D
Mol Cell 2004 Oct 22 16(2):235-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 2 Nov 2004

In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development.
Gerber M, Eissenberg JC, …, Conaway RC, Shilatifard A
Mol Cell Biol 2004 Nov 24(22):9911-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 2 Nov 2004

RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae.
Schneider DA, Nomura M
Proc Natl Acad Sci U S A 2004 Oct 19 101(42):15112-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines / Lucio Comai
Evaluated 26 Oct 2004

mRNA capping enzyme activity is coupled to an early transcription elongation.
Kim HJ, Jeong SH, …, Lee HW, Cho EJ
Mol Cell Biol 2004 Jul 24(14):6184-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 13 Aug 2004

Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene.
Martens JA, Laprade L, Winston F
Nature 2004 Jun 3 429(6991):571-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carl Thummel / Pamela Geyer / Andrew D. Sharrocks / Richard Maraia / Daniel Reines / Mark Bix
Evaluated 6 Jul 2004

Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
Rehwinkel J, Herold A, …, Wilm M, Izaurralde E
Nat Struct Mol Biol 2004 Jun 11(6):558-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 1 Jun 2004

Physical and functional association of RNA polymerase II and the proteasome.
Gillette TG, Gonzalez F, …, Johnston SA, Kodadek T
Proc Natl Acad Sci U S A 2004 Apr 20 101(16):5904-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 23 Apr 2004

Targeted inhibition of V(D)J recombination by a histone methyltransferase.
Osipovich O, Milley R, …, Krangel MS, Oltz EM
Nat Immunol 2004 Mar 5(3):309-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines / David Schatz / Patrick Matthias
Evaluated 19 Mar 2004

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.
Rice JC, Briggs SD, …, Shinkai Y, Allis CD
Mol Cell 2003 Dec 12(6):1591-8 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Reines
Evaluated 3 Feb 2004

Genome-wide analysis of mRNA lengths in Saccharomyces cerevisiae.
Hurowitz EH, Brown PO
Genome Biol 2003 5(1):R2 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 27 Jan 2004

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.
Lum PY, Armour CD, …, Roberts CJ, Shoemaker DD
Cell 2004 Jan 9 116(1):121-37 [abstract on PubMed] [related articles] [order article]
Selected by | Takashi Hirayama / Daniel Reines
Evaluated 22 Jan 2004

Transcription through the roadblocks: the role of RNA polymerase cooperation.
Epshtein V, Toulmé F, …, Borukhov S, Nudler E
EMBO J 2003 Sep 15 22(18):4719-27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 17 Dec 2003

Asymmetry in the assembly of the RNAi enzyme complex.
Schwarz DS, Hutvágner G, …, Aronin N, Zamore PD
Cell 2003 Oct 17 115(2):199-208 [abstract on PubMed] [related articles] [order article]
Selected by | James Carrington / Gregory Hannon / Fritz Eckstein / Daniel Reines
Evaluated 15 Dec 2003

Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation.
Corey LL, Weirich CS, Benjamin IJ, Kingston RE
Genes Dev 2003 Jun 1 17(11):1392-401 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter B. Becker / Daniel Reines
Evaluated 18 Nov 2003

Transcription elongation factors repress transcription initiation from cryptic sites.
Kaplan CD, Laprade L, Winston F
Science 2003 Aug 22 301(5636):1096-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jerry Workman / Daniel Reines
Evaluated 12 Sep 2003

The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation.
Schaft D, Roguev A, …, Neugebauer KM, Stewart AF
Nucleic Acids Res 2003 May 15 31(10):2475-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines
Evaluated 29 Jul 2003

Functional coupling of capping and transcription of mRNA.
Moteki S, Price D
Mol Cell 2002 Sep 10(3):599-609 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Reines
Evaluated 2 May 2003

The poly(A) signal, without the assistance of any downstream element, directs RNA polymerase II to pause in vivo and then to release stochastically from the template.
Orozco IJ, Kim SJ, Martinson HG
J Biol Chem 2002 Nov 8 277(45):42899-911 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Brow / Daniel Reines
Evaluated 28 Apr 2003

Visualizing RNA extrusion and DNA wrapping in transcription elongation complexes of bacterial and eukaryotic RNA polymerases.
Rivetti C, Codeluppi S, Dieci G, Bustamante C
J Mol Biol 2003 Mar 7 326(5):1413-26 [abstract on PubMed] [related articles] [order article]
Selected by | Benoit Coulombe / Daniel Reines
Evaluated 24 Apr 2003

A recombinant RNA polymerase II-like enzyme capable of promoter-specific transcription.
Werner F, Weinzierl RO
Mol Cell 2002 Sep 10(3):635-46 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Reines
Evaluated 13 Feb 2003

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Li B, Howe L, …, Yates JR, Workman JL
J Biol Chem 2003 Mar 14 278(11):8897-903 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Reines / Ronald Conaway
Evaluated 6 Feb 2003