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Robert Kelley
Department of Protein Engineering, Genentech, Inc., South San Francisco, United States of America

Faculty Member: STRUCTURAL BIOLOGY > Biomacromolecule-ligand interactions [ since 11 July 2001 ]
[ Evaluations ]
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Evaluations

Design of protein function leaps by directed domain interface evolution.
Huang J, Koide A, Makabe K, Koide S
Proc Natl Acad Sci U S A 2008 May 6 105(18):6578-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 6 Jun 2008

Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies.
Acierno JP, Braden BC, …, Goldbaum FA, Cauerhff A
J Mol Biol 2007 Nov 16 374(1):130-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 3 Jan 2008

A comprehensive structure-function map of the intracellular surface of the human C5a receptor. II. Elucidation of G protein specificity determinants.
Matsumoto ML, Narzinski K, Nikiforovich GV, Baranski TJ
J Biol Chem 2007 Feb 2 282(5):3122-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 2 Mar 2007

A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues.
Matsumoto ML, Narzinski K, …, Nikiforovich GV, Baranski TJ
J Biol Chem 2007 Feb 2 282(5):3105-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 2 Mar 2007

Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
Luginbühl B, Kanyo Z, …, Burton DR, Plückthun A
J Mol Biol 2006 Oct 13 363(1):75-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley / Carlos F. Barbas
Evaluated 30 Aug 2006

Engineered antibody Fc variants with enhanced effector function.
Lazar GA, Dang W, …, Hayes RJ, Dahiyat BI
Proc Natl Acad Sci U S A 2006 Mar 14 103(11):4005-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 16 Mar 2006

Predicting reactivities of protein surface cysteines as part of a strategy for selective multiple labeling.
Jacob MH, Amir D, …, Gussakowsky E, Haas E
Biochemistry 2005 Oct 25 44(42):13664-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 27 Oct 2005

Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.
Aertgeerts K, Levin I, …, Wijnands R, Tennant MG
J Biol Chem 2005 May 20 280(20):19441-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 25 May 2005

EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.
Koolpe M, Burgess R, Dail M, Pasquale EB
J Biol Chem 2005 Apr 29 280(17):17301-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Kuhn / Robert Kelley
Evaluated 25 May 2005

Use of binding enthalpy to drive an allosteric transition.
Brown PH, Beckett D
Biochemistry 2005 Mar 1 44(8):3112-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 31 Mar 2005

High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
Huxley P, Sutton DH, …, Andersen TB, Classon BJ
Chem Biol 2004 Dec 11(12):1651-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 6 Jan 2005

The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation.
Thomas LR, Johnson RL, Reed JC, Thorburn A
J Biol Chem 2004 Dec 10 279(50):52479-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 6 Jan 2005

Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries.
Harvey BR, Georgiou G, …, Iverson BL, Rogers GK
Proc Natl Acad Sci U S A 2004 Jun 22 101(25):9193-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 23 Nov 2004

Metabolic functionalization of recombinant glycoproteins.
Luchansky SJ, Argade S, Hayes BK, Bertozzi CR
Biochemistry 2004 Sep 28 43(38):12358-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 23 Nov 2004

A systematic method for identifying small-molecule modulators of protein-protein interactions.
Horswill AR, Savinov SN, Benkovic SJ
Proc Natl Acad Sci U S A 2004 Nov 2 101(44):15591-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Kodadek / Robert Kelley / Dorothee Kern
Evaluated 23 Nov 2004

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.
He XL, Garcia KC
Science 2004 May 7 304(5672):870-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley / Phil Barker
Evaluated 17 May 2004

Bypassing a kinase activity with an ATP-competitive drug.
Papa FR, Zhang C, Shokat K, Walter P
Science 2003 Nov 28 302(5650):1533-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Means / Stevan Hubbard / Robert Kelley / Charles Brenner
Evaluated 5 Jan 2004

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
Evaluated 5 Jan 2004

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression.
Anest V, Hanson JL, …, Strahl BD, Baldwin AS
Nature 2003 Jun 5 423(6940):659-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Cope / Christoph Borner / Robert Kelley
Evaluated 5 Jan 2004

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.
Steed PM, Tansey MG, …, Yoder SC, Dahiyat BI
Science 2003 Sep 26 301(5641):1895-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Shiv Pillai / Robert Kelley
Evaluated 2 Jan 2004

Calorimetric determination of thermodynamic parameters of reaction reveals different enthalpic compensations of the yeast hexokinase isozymes.
Bianconi ML
J Biol Chem 2003 May 23 278(21):18709-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 14 Jul 2003

Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis.
Bergstrom RC, Coombs GS, …, Goldsmith EJ, Corey DR
Biochemistry 2003 May 13 42(18):5395-402 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 14 Jul 2003

Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction.
Christensen T, Gooden DM, Kung JE, Toone EJ
J Am Chem Soc 2003 Jun 18 125(24):7357-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 14 Jul 2003

Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation.
Kim HM, Yu KS, …, Lee H, Lee JO
Nat Struct Biol 2003 May 10(5):342-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 8 May 2003

Ligand-receptor binding revealed by the TNF family member TALL-1.
Liu Y, Hong X, …, Dai S, Zhang G
Nature 2003 May 1 423(6935):49-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 8 May 2003

Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.
Skelton NJ, Koehler MF, …, Lasky LA, Sidhu SS
J Biol Chem 2003 Feb 28 278(9):7645-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 4 Apr 2003

Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage.
Liu M, Deora R, …, Parkhill J, Miller JF
Science 2002 Mar 15 295(5562):2091-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joe Heitman / Robert Kelley
Evaluated 4 Apr 2003

Quantifying beta-sheet stability by phage display.
Distefano MD, Zhong A, Cochran AG
J Mol Biol 2002 Sep 6 322(1):179-88 [abstract on PubMed] [related articles] [order article]
Selected by | Robert Kelley
Evaluated 30 Oct 2002

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.
Kayagaki N, Yan M, …, Starovasnik MA, Dixit VM
Immunity 2002 Oct 17(4):515-24 [abstract on PubMed] [related articles] [order article]
Selected by | Robert Kelley / Shiv Pillai
Evaluated 25 Oct 2002

Probing protein electrostatics with a synthetic fluorescent amino acid.
Cohen BE, McAnaney TB, …, Boxer SG, Jan LY
Science 2002 May 31 296(5573):1700-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Deborah Leckband / Peter Qin / Yu-Li Wang / Volkhard Helms / Arieh Warshel / Mario Amzel / Ross Weatherman / Robert Kelley
Evaluated 25 Jul 2002

Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1).
Bienkiewicz EA, Adkins JN, Lumb KJ
Biochemistry 2002 Jan 22 41(3):752-9 [abstract on PubMed] [related articles] [order article]
Selected by | Robert Kelley
Evaluated 6 Mar 2002

Gene defect in ectodermal dysplasia implicates a death domain adapter in development.
Headon DJ, Emmal SA, …, Zonana J, Overbeek PA
Nature 2001 Dec 20-27 414(6866):913-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 10 Jan 2002

Caspase-10 is an initiator caspase in death receptor signaling.
Wang J, Chun HJ, …, Spencer DM, Lenardo MJ
Proc Natl Acad Sci U S A 2001 Nov 20 98(24):13884-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wallach / Robert Kelley
Evaluated 10 Jan 2002

Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding.
Mimura Y, Sondermann P, …, Goodall M, Jefferis R
J Biol Chem 2001 Dec 7 276(49):45539-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 10 Jan 2002

Manipulation of ligand binding affinity by exploitation of conformational coupling.
Marvin JS, Hellinga HW
Nat Struct Biol 2001 Sep 8(9):795-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 4 Dec 2001

Extreme zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR.
Hitomi Y, Outten CE, O'Halloran TV
J Am Chem Soc 2001 Sep 5 123(35):8614-5 [abstract on PubMed] [related articles] [order article]
Selected by | Robert Kelley
Evaluated 21 Nov 2001

Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states.
Ratnaparkhi GS, Varadarajan R
J Biol Chem 2001 Aug 3 276(31):28789-98 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Robert Kelley
Evaluated 10 Oct 2001

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