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Jon Thorson
Department of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, United States of America

Faculty Member: CHEMICAL BIOLOGY > Chemical biology of the cell [ since 17 June 2005 ]
[ Homepage ] [ Evaluations ]
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http://www.pharmacy.wisc.edu/SOPDir/PersonDetails.cfm?&ID=63

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Evaluations

Structure and Mutagenic Conversion of E1 Dehydrase: At the Crossroads of Dehydration, Amino Transfer, and Epimerization.
Smith P, Szu PH, …, Liu HW, Tsai SC
Biochemistry 2008 May 21 0 [abstract on PubMed] [related articles] [full text]
Selected by | Jon Thorson
Evaluated 30 May 2008

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants.
Brazier-Hicks M, Offen WA, …, Davies GJ, Edwards R
Proc Natl Acad Sci U S A 2007 Dec 18 104(51):20238-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 20 Dec 2007

A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones.
Schneider P, Weber M, Rosenberger K, Hoffmeister D
Chem Biol 2007 Jun 14(6):635-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 15 Aug 2007

Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.
Mittler M, Bechthold A, Schulz GE
J Mol Biol 2007 Sep 7 372(1):67-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 3 Jul 2007

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.
Jenni S, Leibundgut M, …, Mikolásek B, Ban N
Science 2007 Apr 13 316(5822):254-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 9 May 2007

Imaging mass spectrometry of neuropeptides in decapod crustacean neuronal tissues.
DeKeyser SS, Kutz-Naber KK, …, Barrett-Wilt GA, Li L
J Proteome Res 2007 May 6(5):1782-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 19 Apr 2007

Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin.
Minami A, Eguchi T
J Am Chem Soc 2007 Apr 25 129(16):5102-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 11 Apr 2007

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.
Bolam DN, Roberts S, …, Davies GJ, Gilbert HJ
Proc Natl Acad Sci U S A 2007 Mar 27 104(13):5336-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jon Thorson
Evaluated 10 Apr 2007

Computational design and experimental evaluation of glycosyltransferase mutants: engineering of a blood type B galactosyltransferase with enhanced glucosyltransferase activity.
Nakahara T, Hindsgaul O, Palcic MM, Nishimura S
Protein Eng Des Sel 2006 Dec 19(12):571-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jon Thorson
Evaluated 8 Dec 2006

Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.
Burlison JA, Neckers L, …, Maxwell A, Blagg BS
J Am Chem Soc 2006 Dec 6 128(48):15529-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 8 Dec 2006

High-throughput screening methodology for the directed evolution of glycosyltransferases.
Aharoni A, Thieme K, …, Wakarchuk WW, Withers SG
Nat Methods 2006 Aug 3(8):609-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda C. Hsieh-Wilson / Jon Thorson
Evaluated 12 Sep 2006

A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation.
Zhou M, O'Doherty GA
Org Lett 2006 Sep 14 8(19):4339-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 12 Sep 2006

Antitumor enediyne chromoprotein C-1027: mechanistic investigation of the chromophore-mediated self-decomposition pathway.
Inoue M, Usuki T, …, Ohie S, Otani T
J Am Chem Soc 2006 Jun 21 128(24):7896-903 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 6 Jul 2006

Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.
Dong C, Flecks S, …, van Pée KH, Naismith JH
Science 2005 Sep 30 309(5744):2216-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jon Thorson / Karen Allen / Mark Nelson
Evaluated 10 Oct 2005

Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme.
Higgins LJ, Yan F, …, Liu HW, Drennan CL
Nature 2005 Oct 6 437(7060):838-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dehua Pei / Jon Thorson
Evaluated 28 Jul 2005

An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose.
Elling L, Rupprath C, …, Kirschning A, Piepersberg W
Chembiochem 2005 Aug 6(8):1423-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 5 Jul 2005

Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency.
Yang M, Proctor MR, …, Gilbert HJ, Davis BG
J Am Chem Soc 2005 Jul 6 127(26):9336-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 4 Jul 2005

Rational saccharide extension by using the natural product glycosyltransferase LanGT4.
Hoffmeister D, Weber M, …, Dürr C, Bechthold A
Chembiochem 2004 Mar 5 5(3):369-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 18 May 2004

Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae.
Zhao L, Beyer NJ, Borisova SA, Liu HW
Biochemistry 2003 Dec 23 42(50):14794-804 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 9 Jan 2004

Formation of 1,1-alpha,alpha-glycosidic bonds by intramolecular aglycone delivery. A convergent synthesis of trehalose.
Pratt MR, Leigh CD, Bertozzi CR
Org Lett 2003 Sep 4 5(18):3185-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 2 Sep 2003

CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin.
Westrich L, Heide L, Li SM
Chembiochem 2003 Aug 4 4(8):768-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 2 Sep 2003

A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.
Christenson SD, Liu W, Toney MD, Shen B
J Am Chem Soc 2003 May 21 125(20):6062-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 12 Jun 2003

Binding and catalysis: a thermodynamic study on a catalytic antibody system.
Wade H, Scanlan TS
Chembiochem 2003 Jun 6 4(6):537-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 9 Jun 2003

The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses.
Hoffmeister D, Dräger G, …, Rohr J, Bechthold A
J Am Chem Soc 2003 Apr 23 125(16):4678-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson
Evaluated 6 Jun 2003

Synthesis of 2,6-dideoxysugars via ring-closing olefinic metathesis.
Andreana PR, McLellan JS, Chen Y, Wang PG
Org Lett 2002 Oct 31 4(22):3875-8 [abstract on PubMed] [related articles] [order article]
Selected by | Jon Thorson
Evaluated 15 Nov 2002

Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
Chen H, Yamase H, …, Zhao Z, Liu HW
Biochemistry 2002 Jul 23 41(29):9165-83 [abstract on PubMed] [related articles] [order article]
Selected by | Jon Thorson
Evaluated 27 Aug 2002

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.
Lewis WG, Green LG, …, Finn MG, Sharpless KB
Angew Chem Int Ed Engl 2002 Mar 15 41(6):1053-7 [abstract on PubMed] [related articles] [order article]
Selected by | Dennis Hall / Jon Thorson
Evaluated 23 Jul 2002

Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.
Cudic P, Kranz JK, …, Weisel JW, McCafferty DG
Proc Natl Acad Sci U S A 2002 May 28 99(11):7384-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jon Thorson
Evaluated 14 Jun 2002

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.
Sánchez C, Butovich IA, …, Méndez C, Salas JA
Chem Biol 2002 Apr 9(4):519-31 [abstract on PubMed] [related articles] [order article]
Selected by | Jon Thorson
Evaluated 20 May 2002

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