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Andrew Lumsden
MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom

Head of Section: Neuroscience > Neurodevelopment [ since 8 June 2001 ]
[ Sponsorship ] [ Biography ] [ Homepage ] [ Evaluations ]
Sponsorship

Andrew Lumsden sponsors free access to F1000 for Tata Institute of Fundamental Research, Mumbai, India. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

Acknowledgements:

Various members of the group assist me with making evaluations for Faculty of 1000: Esther Bell, David Chambers, Jon Gilthorpe, Clemens Kiecker, Robyn Quinlan, Steffen Scholpp, Leigh Wilson, Natalie Harriman and Richard Wingate.


Research interests:

Our research focuses on how regional and cellular identities are established in the vertebrate embryonic nervous system.

We are particularly interested in the mechanisms underlying early neuroepithelial compartmentation and how this prefigures structurally and functionally distinct CNS regions.

A variety of complementary research projects are currently addressing early forebrain and midbrain patterning, the role of Hox genes in hindbrain and branchial arch development, emergence of respiratory rhythm generators in the medulla...and many more.

The laboratory uses a number of different techniques to address genetic and cellular aspects of development:
- microsurgical manipulation
- quail/chick fate map
- cell lineage analysis
- axonal tracing
- confocal microscopy
- retroviral gene transfer
- in ovo electroporation

Home page

http://www.kcl.ac.uk/depsta/biomedical/mrc/index.php

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Evaluations

Epithelial coating controls mesenchymal shape change through tissue-positioning effects and reduction of surface-minimizing tension.
Ninomiya H, Winklbauer R
Nat Cell Biol 2008 Jan 10(1):61-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Herbert Steinbeisser / Andrew Lumsden
Evaluated 7 Mar 2008

Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
Lavado A, Lagutin OV, Oliver G
Development 2008 Feb 135(3):441-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 5 Mar 2008

Control of chemokine-guided cell migration by ligand sequestration.
Boldajipour B, Mahabaleshwar H, …, Xu Q, Raz E
Cell 2008 Feb 8 132(3):463-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lilianna Solnica-Krezel / Andrew Lumsden / Marcus Thelen / Steve Ward / Salim Abdelilah-Seyfried / Alberto Mantovani
Evaluated 21 Feb 2008

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
Fuentealba LC, Eivers E, …, Pera EM, De Robertis EM
Cell 2007 Nov 30 131(5):980-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kimelman / Manfred Frasch / Andrew Lumsden
Evaluated 18 Dec 2007

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.
Overholtzer M, Mailleux AA, …, Cibas ES, Brugge JS
Cell 2007 Nov 30 131(5):966-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharad Kumar / Andrew Lumsden / Eric Baehrecke / Jonathan Chernoff / Gary Bokoch
Evaluated 11 Dec 2007

Cell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme.
Arques CG, Doohan R, Sharpe J, Torres M
Development 2007 Oct 134(20):3713-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 11 Dec 2007

Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription.
Rhee J, Buchan T, …, Lilien J, Balsamo J
Nat Cell Biol 2007 Aug 9(8):883-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 16 Aug 2007

Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria.
Denes AS, Jékely G, …, Balavoine G, Arendt D
Cell 2007 Apr 20 129(2):277-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Max Telford / James Briscoe / Andrew Lumsden / Judith S. Eisen / Patricia Simpson
Evaluated 3 May 2007

Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation.
Manning L, Ohyama K, …, Logan M, Placzek M
Dev Cell 2006 Dec 11(6):873-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 16 Apr 2007

Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages.
Endo K, Aoki T, …, Kimura K, Hama C
Nat Neurosci 2007 Feb 10(2):153-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 16 Mar 2007

Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome.
Davy A, Bush JO, Soriano P
PLoS Biol 2006 Sep 4(10):e315 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Chisholm / Andrew Lumsden
Evaluated 9 Nov 2006

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Cappello S, Attardo A, …, Brakebusch C, Götz M
Nat Neurosci 2006 Sep 9(9):1099-107 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Keith Mostov / Sally Temple / Andrew Lumsden / Orly Reiner
Evaluated 19 Sep 2006

Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map.
Oury F, Murakami Y, …, Ren SY, Rijli FM
Science 2006 Sep 8 313(5792):1408-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Graham / Andrew Lumsden
Evaluated 14 Sep 2006

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Salehi A, Delcroix JD, …, Goldstein LS, Mobley WC
Neuron 2006 Jul 6 51(1):29-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Robertson / David Ginty / Andrew Lumsden
Evaluated 18 Aug 2006

The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.
Liu JP
Development 2006 Aug 133(15):2865-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Harukazu Nakamura / Andrew Lumsden
Evaluated 19 Jul 2006

Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression.
Iimura T, Pourquié O
Nature 2006 Aug 3 442(7102):568-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden / Peter Scambler / Denis Duboule / Filippo Rijli
Evaluated 19 Jul 2006

Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
López-Bendito G, Cautinat A, …, Marín O, Garel S
Cell 2006 Apr 7 125(1):127-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gordon Fishell / Alain Prochiantz / Andrew Lumsden / M. Angela Nieto
Evaluated 3 May 2006

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation.
Corrales JD, Blaess S, Mahoney EM, Joyner AL
Development 2006 May 133(9):1811-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden / Harukazu Nakamura
Evaluated 30 Mar 2006

Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5.
Nomura T, Holmberg J, Frisen J, Osumi N
Development 2006 Apr 133(7):1335-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 3 Mar 2006

Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway.
Lee HS, Bong YS, …, Moody SA, Daar IO
Nat Cell Biol 2006 Jan 8(1):55-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden / Norbert Perrimon / Catherine Krull
Evaluated 9 Jan 2006

In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog.
Ahn S, Joyner AL
Nature 2005 Oct 6 437(7060):894-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden / Valeri Vasioukhin
Evaluated 22 Nov 2005

The transmembrane semaphorin Sema6A controls cerebellar granule cell migration.
Kerjan G, Dolan J, …, Mitchell KJ, Chédotal A
Nat Neurosci 2005 Nov 8(11):1516-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 22 Nov 2005

Assembly of trigeminal sensory ganglia by chemokine signaling.
Knaut H, Blader P, Strähle U, Schier AF
Neuron 2005 Sep 1 47(5):653-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 22 Nov 2005

Notch signaling coordinates the patterning of striatal compartments.
Mason HA, Rakowiecki SM, …, Gridley T, Fishell G
Development 2005 Oct 132(19):4247-58 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 14 Sep 2005

Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing.
Major RJ, Irvine KD
Development 2005 Sep 132(17):3823-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Wilkinson / Andrew Lumsden / Mary Baylies
Evaluated 17 Aug 2005

Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression.
Sirbu IO, Gresh L, Barra J, Duester G
Development 2005 Jun 132(11):2611-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 24 May 2005

Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
Tao Q, Yokota C, …, Lin X, Heasman J
Cell 2005 Mar 25 120(6):857-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kimelman / Andrew Lumsden / Herbert Steinbeisser
Evaluated 4 Apr 2005

EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish.
Cooke JE, Kemp HA, Moens CB
Curr Biol 2005 Mar 29 15(6):536-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wilkinson / Andrew Lumsden / Paul Garrity
Evaluated 4 Apr 2005

Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo.
Williams PH, Hagemann A, González-Gaitán M, Smith JC
Curr Biol 2004 Nov 9 14(21):1916-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Claudio Stern / Andrew Lumsden
Evaluated 31 Jan 2005

Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.
Hori K, Fostier M, …, Baron M, Matsuno K
Development 2004 Nov 131(22):5527-37 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mark Fortini / Andrew Lumsden
Evaluated 23 Nov 2004

Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins.
Tayler TD, Robichaux MB, Garrity PA
Development 2004 Dec 131(23):5935-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 23 Nov 2004

Do morphogen gradients arise by diffusion?
Lander AD, Nie Q, Wan FY
Dev Cell 2002 Jun 2(6):785-96 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathan Slack / Siegfried Roth / Andrew Lumsden
Evaluated 16 Jul 2002

Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.
Belenkaya TY, Han C, …, Liu H, Lin X
Cell 2004 Oct 15 119(2):231-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden / Ken Irvine / Deborah Andrew / Jean-Paul Vincent / Jeffrey Axelrod / Alain Prochiantz
Dissenters | Alfonso Martinez Arias
Author Response | Xinhua Lin
Evaluated 26 Oct 2004


Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity.
Chesnutt C, Burrus LW, Brown AM, Niswander L
Dev Biol 2004 Oct 15 274(2):334-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 11 Oct 2004

Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements.
Lanuza GM, Gosgnach S, …, Jessell TM, Goulding M
Neuron 2004 May 13 42(3):375-86 [abstract on PubMed] [related articles] [order article]
Selected by | Ole Kiehn / Keith Sillar / Jack Feldman / Andrew Lumsden
Evaluated 19 Aug 2004

Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling.
Onai T, Sasai N, Matsui M, Sasai Y
Dev Cell 2004 Jul 7(1):95-106 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden
Evaluated 30 Jul 2004

A role for MKP3 in axial patterning of the zebrafish embryo.
Tsang M, Maegawa S, …, Weinberg E, Dawid IB
Development 2004 Jun 131(12):2769-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden / Ben Zion Shilo
Evaluated 10 Jun 2004

Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila.
Fuss B, Josten F, Feix M, Hoch M
Development 2004 Apr 131(7):1587-95 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 10 Mar 2004

Foxg1 suppresses early cortical cell fate.
Hanashima C, Li SC, …, Lai E, Fishell G
Science 2004 Jan 2 303(5654):56-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Christopher A. Walsh / Andrew Lumsden / Judith S. Eisen
Evaluated 15 Jan 2004

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.
Pera EM, Ikeda A, Eivers E, De Robertis EM
Genes Dev 2003 Dec 15 17(24):3023-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden / David Wotton
Evaluated 13 Jan 2004

Vertebrate neurogenesis is counteracted by Sox1-3 activity.
Bylund M, Andersson E, Novitch BG, Muhr J
Nat Neurosci 2003 Nov 6(11):1162-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Briscoe / Andrew Lumsden / Francois Guillemot
Evaluated 18 Nov 2003

Vertebrate HoxB gene expression requires DNA replication.
Fisher D, Méchali M
EMBO J 2003 Jul 15 22(14):3737-48 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 10 Sep 2003

Smoothened translates Hedgehog levels into distinct responses.
Hooper JE
Development 2003 Sep 130(17):3951-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 5 Aug 2003

Single-cell transcriptional analysis of neuronal progenitors.
Tietjen I, Rihel JM, …, Zakhary L, Dulac C
Neuron 2003 Apr 24 38(2):161-75 [abstract on PubMed] [related articles] [order article]
Selected by | Andrew Lumsden
Evaluated 8 Jul 2003

Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors.
Lee SK, Pfaff SL
Neuron 2003 Jun 5 38(5):731-45 [abstract on PubMed] [related articles] [order article]
Selected by | Gordon Fishell / Judith S. Eisen / Andrew Lumsden
Evaluated 7 Jul 2003

The Opitz syndrome gene MID1 is essential for establishing asymmetric gene expression in Hensen's node.
Granata A, Quaderi NA
Dev Biol 2003 Jun 15 258(2):397-405 [abstract on PubMed] [related articles] [order article]
Selected by | Andrew Lumsden
Evaluated 19 May 2003

Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.
Cordenonsi M, Dupont S, …, Imbriano C, Piccolo S
Cell 2003 May 2 113(3):301-14 [abstract on PubMed] [related articles] [order article]
Selected by | David Kimelman / Andrew Lumsden / Victor Thannickal
Evaluated 19 May 2003

Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code.
Allan DW, St Pierre SE, Miguel-Aliaga I, Thor S
Cell 2003 Apr 4 113(1):73-86 [abstract on PubMed] [related articles] [order article]
Selected by | Andrew Lumsden
Evaluated 15 Apr 2003

Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons.
Grueber WB, Jan LY, Jan YN
Cell 2003 Mar 21 112(6):805-18 [abstract on PubMed] [related articles] [order article]
Selected by | Silvia Arber / Andrew Lumsden / Alain Prochiantz
Evaluated 15 Apr 2003

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.
Charron F, Stein E, …, McMahon AP, Tessier-Lavigne M
Cell 2003 Apr 4 113(1):11-23 [abstract on PubMed] [related articles] [order article]
Selected by | Andrew Lumsden / Gordon Fishell / Judith S. Eisen
Evaluated 2 Apr 2003

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.
Hsieh JC, Lee L, …, Rosenquist T, Holdener BC
Cell 2003 Feb 7 112(3):355-67 [abstract on PubMed] [related articles] [order article]
Selected by | Andrew Lumsden
Evaluated 2 Apr 2003

Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.
Culi J, Mann RS
Cell 2003 Feb 7 112(3):343-54 [abstract on PubMed] [related articles] [order article]
Selected by | Jessica E. Treisman / Joachim Herz / Andrew Lumsden
Evaluated 2 Apr 2003

Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch.
Rank G, Prestel M, Paro R
Mol Cell Biol 2002 Nov 22(22):8026-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rob White / Andrew Lumsden / Thomas Jenuwein
Evaluated 13 Jan 2003

Cell dynamics during somite boundary formation revealed by time-lapse analysis.
Kulesa PM, Fraser SE
Science 2002 Nov 1 298(5595):991-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 13 Jan 2003

Transcription activates repressed domains in the Drosophila bithorax complex.
Bender W, Fitzgerald DP
Development 2002 Nov 129(21):4923-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 13 Jan 2003

Transcription through the iab-7 cis-regulatory domain of the bithorax complex interferes with maintenance of Polycomb-mediated silencing.
Hogga I, Karch F
Development 2002 Nov 129(21):4915-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Lumsden
Evaluated 13 Jan 2003

Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
Perea-Gomez A, Vella FD, …, Behringer RR, Ang SL
Dev Cell 2002 Nov 3(5):745-56 [abstract on PubMed] [related articles] [order article]
Selected by | David Kimelman / Daniel Constam / Andrew Lumsden
Evaluated 25 Nov 2002

The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling.
Bertocchini F, Stern CD
Dev Cell 2002 Nov 3(5):735-44 [abstract on PubMed] [related articles] [order article]
Selected by | David Kimelman / Andrew Lumsden
Evaluated 25 Nov 2002

Medulloblastoma growth inhibition by hedgehog pathway blockade.
Berman DM, Karhadkar SS, …, Olson JM, Beachy PA
Science 2002 Aug 30 297(5586):1559-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lee Rubin / Alexandra Joyner / Andrew Lumsden
Evaluated 26 Sep 2002

Patched acts catalytically to suppress the activity of Smoothened.
Taipale J, Cooper MK, Maiti T, Beachy PA
Nature 2002 Aug 22 418(6900):892-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michel Labouesse / Alexandra Joyner / Andrew Lumsden / Marek Mlodzik
Evaluated 26 Sep 2002

LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
Thaler JP, Lee SK, …, Gill GN, Pfaff SL
Cell 2002 Jul 26 110(2):237-49 [abstract on PubMed] [related articles] [order article]
Selected by | Judith S. Eisen / Andrew Lumsden
Evaluated 24 Sep 2002

Directed differentiation of embryonic stem cells into motor neurons.
Wichterle H, Lieberam I, Porter JA, Jessell TM
Cell 2002 Aug 9 110(3):385-97 [abstract on PubMed] [related articles] [order article]
Selected by | Constance Scharff / Sally Temple / Andrew Lumsden
Evaluated 24 Sep 2002

Construct conversions caused by simultaneous co-transfection: "GFP-walking".
Bestvater F, Knoch TA, Langowski J, Spiess E
Biotechniques 2002 Apr 32(4):844, 846, 848-50 passim [abstract on PubMed] [related articles] [order article]
Selected by | Andrew Lumsden
Evaluated 15 Aug 2002